| Effects of heterocyclic amines in food on dopamine metabolism in nigro-striatal dopaminergic neurons. | |
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MedLine Citation:
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PMID: 2900009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of 14 heterocyclic amines in food on nigro-striatal dopaminergic neurons. Among 14 compounds tested, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) caused substantial decreases in 3,4-dihydroxy-phenylalanine (DOPA) formation in striatal tissue slice system. When Trp-P-1 or Trp-P-2 was unilaterally infused in the rat striatum by an in vivo micro-dialysis technique, both compounds produced a transient increase of dopamine (DA) and continuous decreases in the metabolites, homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the perfusate. This suggests that the two compounds inhibit monoamine oxidase (MAO) in vivo. Indeed they were found to be very potent inhibitors of MAO in vitro. Systemic administration of Trp-P-1 to C57 Black mice caused a marked decrease of DOPAC content and a significant increase of DA in the striatum, indicating inhibition of MAO in vivo. These results suggest that Trp-P-1 and Trp-P-2 contained in food could alter the metabolism of DA in the brain. |
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Authors:
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H Ichinose; N Ozaki; D Nakahara; M Naoi; K Wakabayashi; T Sugimura; T Nagatsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical pharmacology Volume: 37 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-09-07 Completed Date: 1988-09-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3289-95 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Nagoya University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Amines / pharmacology* Corpus Striatum / metabolism* Dopamine / metabolism* Food Heterocyclic Compounds / pharmacology* Homovanillic Acid / metabolism Kinetics Monoamine Oxidase / metabolism Monoamine Oxidase Inhibitors Neurons / metabolism Substantia Nigra / metabolism* Tyrosine 3-Monooxygenase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Heterocyclic Compounds; 0/Monoamine Oxidase Inhibitors; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; EC 1.14.16.2/Tyrosine 3-Monooxygenase; EC 1.4.3.4/Monoamine Oxidase |
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