Document Detail

Effects of heterocyclic amines in food on dopamine metabolism in nigro-striatal dopaminergic neurons.
MedLine Citation:
PMID:  2900009     Owner:  NLM     Status:  MEDLINE    
We investigated the effects of 14 heterocyclic amines in food on nigro-striatal dopaminergic neurons. Among 14 compounds tested, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) caused substantial decreases in 3,4-dihydroxy-phenylalanine (DOPA) formation in striatal tissue slice system. When Trp-P-1 or Trp-P-2 was unilaterally infused in the rat striatum by an in vivo micro-dialysis technique, both compounds produced a transient increase of dopamine (DA) and continuous decreases in the metabolites, homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the perfusate. This suggests that the two compounds inhibit monoamine oxidase (MAO) in vivo. Indeed they were found to be very potent inhibitors of MAO in vitro. Systemic administration of Trp-P-1 to C57 Black mice caused a marked decrease of DOPAC content and a significant increase of DA in the striatum, indicating inhibition of MAO in vivo. These results suggest that Trp-P-1 and Trp-P-2 contained in food could alter the metabolism of DA in the brain.
H Ichinose; N Ozaki; D Nakahara; M Naoi; K Wakabayashi; T Sugimura; T Nagatsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  37     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-09-07     Completed Date:  1988-09-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3289-95     Citation Subset:  IM    
Department of Biochemistry, Nagoya University School of Medicine, Japan.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Amines / pharmacology*
Corpus Striatum / metabolism*
Dopamine / metabolism*
Heterocyclic Compounds / pharmacology*
Homovanillic Acid / metabolism
Monoamine Oxidase / metabolism
Monoamine Oxidase Inhibitors
Neurons / metabolism
Substantia Nigra / metabolism*
Tyrosine 3-Monooxygenase / metabolism
Reg. No./Substance:
0/Amines; 0/Heterocyclic Compounds; 0/Monoamine Oxidase Inhibitors; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; EC 3-Monooxygenase; EC Oxidase

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