| Effects of hetastarch and mannitol on prolonging survival in stable hypothermia in rats. | |
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MedLine Citation:
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PMID: 10749793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In rats, prolonged stable hypothermia ( approximately 24 h at body temperature of 19 degrees C) is characterized by a time-dependent increase in hematocrit, plasma osmolality, and red blood cell fragility and a decrease in plasma volume. These changes impede tissue microcirculation and could limit survival. As a countermeasure, we used plasma volume expanders of both long (hetastarch)- and short-lasting (mannitol) characteristics to improve microcirculation and hopefully hypothermia survival. Infusion of 6% hetastarch at hour 3 in hypothermia significantly (P < 0.05) enhanced survival over saline control (33.5 vs. 23.8 h); a significant delay in the increases of hematocrit and cell fragility was also observed compared with those in saline controls. Treating the animal with 6% hetastarch at hour 20 during hypothermia caused a similar but less-effective improvement in survival. In contrast, treating the rats with 6% mannitol at hour 3 or 20 during hypothermia failed to enhance survival over saline control, although transient improvement in plasma volume was observed. Our results indicate that by using a long-lasting volume expander, which tends to better maintain plasma volume and rheological parameters governing microcirculation than does saline or a short-lasting volume expander, hypothermia survival can be significantly improved. |
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Authors:
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T F Lee; J Westly; L C Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 278 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-05-04 Completed Date: 2000-05-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R1040-7 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Volume Diuretics, Osmotic / pharmacology* Erythrocyte Deformability Hematocrit Hetastarch / pharmacology* Hypothermia / drug therapy*, mortality Male Mannitol / pharmacology* Microcirculation / physiology Osmolar Concentration Plasma Substitutes / pharmacology* Rats Rats, Sprague-Dawley Sodium Chloride / pharmacology Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Diuretics, Osmotic; 0/Plasma Substitutes; 69-65-8/Mannitol; 7647-14-5/Sodium Chloride; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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