| Effects of the herbal medicine Inchinko-to on liver function in postoperative patients with biliary atresia--a pilot study. | |
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MedLine Citation:
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PMID: 14614709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/PURPOSE: A continuation of liver fibrosis after undergoing successful Kasai operation has become the important clinical issue in the long-term follow-up of patients with biliary atresia (BA). The aim of this study is to evaluate the efficacy of the herbal medicine Inchinko-to (TJ-135) on the treatment of liver fibrosis in patients with BA without jaundice, especially from the viewpoint of the long-term effects of TJ-135. METHODS: Six postoperative patients with BA ranging between 3 and 13 years of age with normal serum total bilirubin levels (total bilirubin < 1.0 mg/dL [17 micromol/L]) received TJ-135 from 2 to 4 years. The liver enzyme (glutamic oxaloacetic transaminase [GOT], glutamic pyruvic transaminase [GPT], gamma glutamyl transpeptidase[gamma-GTP]transpeptidase[gamma-GTP] levels and hyaluronic acid (HA) levels were compared before and after the administration of TJ-135. The monthly collected data were averaged on a 1-year basis. The record of one postoperative patient with BA and a normal serum total bilirubin level was incorporated as a control. This patient showed portal hypertension and did not receive TJ-135. RESULTS: Five of the six patients who showed abnormal values for liver enzymes, exhibited a significant decrease in serum GOT, gamma-GTP, or GPT levels after a 1 to 3-year administration of TJ-135, and the improvement in these parameters persisted thereafter. Furthermore, one patient who had an abnormally high value of HA also showed a significant decrease in the serum level of HA. In the remaining patient with normal liver enzyme values, no significant change was observed during the administration of TJ-135. The control patient exhibited a chronological decrease in the serum GOT and GPT levels by 5 years of age, but the serum gamma-GTP and HA levels remained stable throughout the postoperative period. CONCLUSIONS: The long-term effectiveness of TJ-135 was only found in those patients with abnormal liver enzyme levels and HA, thereby suggesting that TJ-135 has a protective and antifibrotic effect on the liver. |
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Authors:
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Yasushi Iinuma; Masayuki Kubota; Minoru Yagi; Satoshi Kanada; Satoru Yamazaki; Yoshiaki Kinoshita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 38 ISSN: 1531-5037 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1607-11 Citation Subset: IM |
Affiliation:
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Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Niigata, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alanine Transaminase / blood Aspartate Aminotransferases / blood Biliary Atresia / surgery* Child Child, Preschool Drug Evaluation Drug Therapy, Combination Drugs, Chinese Herbal / administration & dosage, therapeutic use* Female Follow-Up Studies Humans Hyaluronic Acid / blood Liver / drug effects*, surgery Liver Cirrhosis / prevention & control* Male Pilot Projects Postoperative Complications / prevention & control* Taurine / therapeutic use Ursodeoxycholic Acid / therapeutic use gamma-Glutamyltransferase / blood |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/inchinko-to; 107-35-7/Taurine; 128-13-2/Ursodeoxycholic Acid; 9004-61-9/Hyaluronic Acid; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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