Document Detail


Effects of the herbal medicine Inchinko-to on liver function in postoperative patients with biliary atresia--a pilot study.
MedLine Citation:
PMID:  14614709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: A continuation of liver fibrosis after undergoing successful Kasai operation has become the important clinical issue in the long-term follow-up of patients with biliary atresia (BA). The aim of this study is to evaluate the efficacy of the herbal medicine Inchinko-to (TJ-135) on the treatment of liver fibrosis in patients with BA without jaundice, especially from the viewpoint of the long-term effects of TJ-135. METHODS: Six postoperative patients with BA ranging between 3 and 13 years of age with normal serum total bilirubin levels (total bilirubin < 1.0 mg/dL [17 micromol/L]) received TJ-135 from 2 to 4 years. The liver enzyme (glutamic oxaloacetic transaminase [GOT], glutamic pyruvic transaminase [GPT], gamma glutamyl transpeptidase[gamma-GTP]transpeptidase[gamma-GTP] levels and hyaluronic acid (HA) levels were compared before and after the administration of TJ-135. The monthly collected data were averaged on a 1-year basis. The record of one postoperative patient with BA and a normal serum total bilirubin level was incorporated as a control. This patient showed portal hypertension and did not receive TJ-135. RESULTS: Five of the six patients who showed abnormal values for liver enzymes, exhibited a significant decrease in serum GOT, gamma-GTP, or GPT levels after a 1 to 3-year administration of TJ-135, and the improvement in these parameters persisted thereafter. Furthermore, one patient who had an abnormally high value of HA also showed a significant decrease in the serum level of HA. In the remaining patient with normal liver enzyme values, no significant change was observed during the administration of TJ-135. The control patient exhibited a chronological decrease in the serum GOT and GPT levels by 5 years of age, but the serum gamma-GTP and HA levels remained stable throughout the postoperative period. CONCLUSIONS: The long-term effectiveness of TJ-135 was only found in those patients with abnormal liver enzyme levels and HA, thereby suggesting that TJ-135 has a protective and antifibrotic effect on the liver.
Authors:
Yasushi Iinuma; Masayuki Kubota; Minoru Yagi; Satoshi Kanada; Satoru Yamazaki; Yoshiaki Kinoshita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  38     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1607-11     Citation Subset:  IM    
Affiliation:
Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata-City, Niigata, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Biliary Atresia / surgery*
Child
Child, Preschool
Drug Evaluation
Drug Therapy, Combination
Drugs, Chinese Herbal / administration & dosage,  therapeutic use*
Female
Follow-Up Studies
Humans
Hyaluronic Acid / blood
Liver / drug effects*,  surgery
Liver Cirrhosis / prevention & control*
Male
Pilot Projects
Postoperative Complications / prevention & control*
Taurine / therapeutic use
Ursodeoxycholic Acid / therapeutic use
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/inchinko-to; 107-35-7/Taurine; 128-13-2/Ursodeoxycholic Acid; 9004-61-9/Hyaluronic Acid; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

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