Document Detail

Effects of the herbal formulation ColiMil on upper gastrointestinal transit in mice in vivo.
MedLine Citation:
PMID:  17582592     Owner:  NLM     Status:  MEDLINE    
Clinical evidence suggests that the herbal formulation ColiMil (which contains Matricaria recutita flowers extract, Foeniculum vulgare fruit extract and Melissa officinalis aerial parts extract) is effective in the treatment of breastfed colic in infants. Therefore the effect of this phytotherapeutic formulation and its herbal constituents on upper gastrointestinal transit was investigated in mice in vivo. Oral administration of the herbal formulation (0.4-0.8 mL/mice) dose-dependently delayed upper gastrointestinal transit. Among the herbal components, Matricaria recutita extract (0.89 and 1.78 mg/mouse) and Melissa officinalis extract (6.46 and 12.92 mg/mouse), but not Foeniculum vulgare (8.21 and 16.42 mg/mouse), reduced motility significantly. These results suggest that ColiMil reduces upper gastrointestinal motility in mice, with a major contribution by Matricaria recutita and Melissa officinalis. These experimental data may be important to better understand the observation that the herbal formulation ColiMil improves colic in breastfed infants.
Raffaele Capasso; Francesco Savino; Francesco Capasso
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  21     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-26     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  999-1101     Citation Subset:  IM    
Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples Italy.
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MeSH Terms
Croton Oil / pharmacology
Drug Synergism
Foeniculum / chemistry
Gastrointestinal Transit / drug effects*
Matricaria / chemistry
Melissa / chemistry
Mice, Inbred ICR
Plant Extracts / chemistry,  pharmacology*
Reg. No./Substance:
0/ColiMil; 0/Plant Extracts; 8001-28-3/Croton Oil

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