| Effects of hepatectomy and arginine enriched diet on colonic mucosa originated inflammatory cytokines. | |
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MedLine Citation:
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PMID: 14569477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the effects of arginine-enriched diet and partial hepatectomy in rats on gut-originated inflammatory cytokines. METHODS: Of 24 rats, Group 1 and 2 animals were fasted 24 hours before surgery, Group 3 and 4 animals received regular plus arginine-enriched diet(AED). Group 2 and 4 animals had undergone 30% hepatic resection. Leukotriene B4 (LT B4) levels were detected in colonic mucosa and mucosal perfusates immediately after resection. Mean leukocyte counts (MLC) were detected also in the mucosa. RESULTS: In the basis of fasting situation regardless hepatectomy, all MLC were lower in Group 3 and 4 but LTB4 levels both in mucosa and perfusate were higher. On hepatectomy based comparison there was not any statistically significant difference between groups but mucosal perfusate LTB4 levels. But when hepatectomy added on fasted animals MLC levels were lower than fed by AED + sham operation. LTB4 levels were insignificant in both perfusate and mucosa. When hepatectomy added on AED animals (Group 4), MLC decreased and mucosal LTB4 increased when they compared with fast without hepatectomy Group 1. CONCLUSIONS: AED prior to extra-intestinal operations may trigger inflammatory cascade and complications via leucocyte degradation and LTB4. |
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Authors:
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Cengiz Aydin; Ahmet Coker; Koray Atilla; Erdener Ozer; Isil Coker; Afig Huseyinov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES Volume: 9 ISSN: 1306-696X ISO Abbreviation: Ulus Travma Acil Cerrahi Derg Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-21 Completed Date: 2004-02-24 Revised Date: 2006-05-04 |
Medline Journal Info:
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Nlm Unique ID: 101274231 Medline TA: Ulus Travma Acil Cerrahi Derg Country: Turkey |
Other Details:
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Languages: eng Pagination: 232-8 Citation Subset: IM |
Affiliation:
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Dokuz Eylul University Hospital, Dept. of Surgery, Izmir, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / administration & dosage* Colon / drug effects*, immunology Dietary Supplements* Hepatectomy* Intestinal Mucosa / drug effects, immunology Leukocytes / metabolism Leukotriene B4 / metabolism* Random Allocation Rats |
| Chemical | |
Reg. No./Substance:
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71160-24-2/Leukotriene B4; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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