Document Detail


Effects of heparin on vascularization of artificial skin grafts in rats.
MedLine Citation:
PMID:  2450779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Artificial skin is a recent development in the clinical care of the severely burned patient. Its manufacture entails the covalent bonding of collagen and polysaccharide, followed by the coating of one surface with a thin layer of silicone rubber. Artificial skin was grafted onto rats and examined for neovascularization at 7 days. Vascular patency was shown by perfused yellow latex casts. Five percent of the patent vessels grew into the graft soaked in physiological buffered saline (PBS). When the graft was soaked in heparin, 1 mg/ml buffered saline solution, before grafting, 54% of the patent vessels in the grafted area had grown into the matrix. These experiments show that the local application of heparin promotes early ingrowth of blood vessels into the healing site. The vascularity of artificial skin can be modified by heparin, which promotes angiogenesis, and leads to earlier deposits of greater amounts of new connective tissue.
Authors:
H P Ehrlich; W K Jung; D E Costa; J B Rajaratnam
Related Documents :
15606849 - Useful adjuncts to harvest split-thickness skin grafts.
3577939 - Reconstruction of the face by means of the angle-rotation flap.
11761389 - Prospective trial of thick vs standard split-thickness skin grafts in burns of the hand.
11289619 - Suprafascial dissection of the radial forearm flap and donor site morbidity.
790749 - Iatrogenic microphallus secondary to circumcision.
15509929 - Leave the fat, skip the bolster: thinking outside the box in lower third nasal reconstr...
23631489 - Porcine skin gelatin hydrolysate promotes longitudinal bone growth in adolescent rats.
22226889 - Why haematomas cause flap failure: an evidence-based paradigm.
24695929 - Declining rates of osteoporosis management following fragility fractures in the u.s., 2...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental and molecular pathology     Volume:  48     ISSN:  0014-4800     ISO Abbreviation:  Exp. Mol. Pathol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370711     Medline TA:  Exp Mol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-51     Citation Subset:  IM    
Affiliation:
Shriners Burns Institute, Massachusetts General Hospital, Boston 02114.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Heparin / pharmacology*
Neovascularization, Pathologic
Rats
Rats, Inbred Strains
Skin / blood supply
Skin Transplantation*
Grant Support
ID/Acronym/Agency:
GM 21700/GM/NIGMS NIH HHS; GM 25561/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanisms of regulation of ferritin synthesis in rat liver during experimental inflammation.
Next Document:  Glycogen synthase from human and bovine polymorphonuclear leukocyte. Immunochemical characterization...