| Effects of heparin, desmopressin, and isovolemic hemodilution with dextran on thrombus formation in synthetic vessel grafts inserted into the vena cava of the rabbit. | |
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MedLine Citation:
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PMID: 9737461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to investigate the effects of isovolemic hemodilution with dextran-70 on thrombus formation and blood flow in synthetic venous vessel grafts. Polytetrafluoroethylene grafts (length, 11 mm; inner diameter, 3 mm) were inserted into the vena cava of rabbits. Six groups were studied: (1) the control group; (2) animals that underwent isovolemic hemodilution with dextran-70 to a hematocrit of about 30%; (3) animals that underwent isovolemic dextran hemodilution combined with a bolus injection of heparin; (4) animals that underwent heparin treatment only; (5) animals that underwent isovolemic dextran hemodilution combined with infusion of desmopressin; and (6) animals that underwent an identical treatment to group 3 but with a 2-week, instead of a 2-day, follow-up. Vena cava blood flow was measured before and after hemodilution and graft insertion and at the termination of the experiments at 2 days (groups 1 to 5) and 2 weeks (group 6) after surgery. Graft patency and thrombus mass weight were evaluated. In the control group, most of the vessels occluded within 2 days. Hemodilution with dextran improved blood flow and reduced thrombus mass weight significantly. Desmopressin, which increases factor VIII, did not influence the effects of hemodilution with dextran, which suggests that the effects of dextran are not mediated by a reduction in the level of this coagulation factor. A single bolus dose of heparin did not reduce thrombus formation in the grafts but did potentiate the effects of isovolemic hemodilution on thrombus mass and graft blood flow. We conclude that isovolemic dextran hemodilution combined with a single bolus of heparin had beneficial long-lasting effects. The grafts in groups 3 and 6 were all patent. |
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Authors:
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L Frost-Arner; D Bergqvist |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 28 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-09-25 Completed Date: 1998-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 506-13 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Malmö University Hospital, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / administration & dosage, pharmacology* Blood Vessel Prosthesis Implantation* Deamino Arginine Vasopressin / administration & dosage, pharmacology* Dextrans / administration & dosage* Female Hemodilution / methods* Heparin / administration & dosage, pharmacology* Male Polytetrafluoroethylene Rabbits Thrombosis / prevention & control* Vascular Patency Vena Cava, Inferior* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 16679-58-6/Deamino Arginine Vasopressin; 9002-84-0/Polytetrafluoroethylene; 9004-54-0/Dextrans; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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