| Effects of heparin and dalteparin on oxidative stress during hemodialysis in patients with end-stage renal disease. | |
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MedLine Citation:
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PMID: 19617666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Dialysis-induced oxidative stress is one of the mechanisms of atherosclerotic changes. Heparin, used in hemodialysis, is an anticoagulant drug with anti-inflammatory and antioxidant effects. This study was planned in order to evaluate the antioxidant effects of heparin and dalteparin (low-molecular weight heparin). MATERIALS AND METHODS: Twenty-two patients underwent 3 hemodialysis sessions with 48-hour intervals. They underwent hemodialysis with heparin, with a bolus dose of 1000 U followed by 1000 U/h during the procedure. The second hemodialysis was done using hypertonic saline solution instead of heparin, and the third, using dalteparin, 4000 U, infused during hemodialysis. Before and after each dialysis session, we measured serum levels of total blood cholesterol, triglyceride, high- and low-density lipoprotein cholesterols and oxidized low-density lipoprotein cholesterol, in addition to total antioxidant capacity and paraoxonase 1 activity. RESULTS: Serum concentrations of triglyceride, cholesterol, and oxidized low-density lipoprotein cholesterol, as well as paraoxonase activity and total antioxidant capacity equally increased after the three hemodialysis sessions. Heparin and daltepain increased total antioxidant capacity, but they did not change the ratio of paraoxonase 1 to high-density lipoprotein cholesterol after hemodialysis. No significant differences were found through the study between the two heparin products in their antioxidant activities. CONCLUSIONS: Regarding these findings and considering higher price and less availability of dalteparin in comparison to conventional heparin, we recommend using conventional heparin during hemodialysis as the anticoagulant-antioxidant agent. |
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Authors:
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Amir Ahmad Nassiri; Monir Sadat Hakemi; Mehrdad Soulati; Mehran Marashian; Khosrow Rahbar; Fereidoun Azizi |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Iranian journal of kidney diseases Volume: 3 ISSN: 1735-8582 ISO Abbreviation: Iran J Kidney Dis Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-10-16 Revised Date: 2010-02-22 |
Medline Journal Info:
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Nlm Unique ID: 101316967 Medline TA: Iran J Kidney Dis Country: Iran |
Other Details:
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Languages: eng Pagination: 162-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran. nassiri@ams.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticoagulants / administration & dosage*, economics Aryldialkylphosphatase / blood Dalteparin / administration & dosage*, economics Drug Costs Female Heparin / administration & dosage*, economics Humans Kidney Failure, Chronic / economics, therapy* Lipoproteins, HDL / blood Lipoproteins, LDL / blood Male Middle Aged Oxidative Stress / drug effects* Renal Dialysis* Thrombosis / economics, prevention & control Triglycerides / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Dalteparin; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 0/oxidized low density lipoprotein; 9005-49-6/Heparin; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human |
| Comments/Corrections | |
Erratum In:
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Iran J Kidney Dis. 2009 Oct;3(4):255 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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