Document Detail

Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery.
MedLine Citation:
PMID:  8895264     Owner:  NLM     Status:  MEDLINE    
We conducted a pilot study to evaluate the effects of HBOC-201, a bovine hemoglobin-based oxygen carrier, on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. After induction of anesthesia and isovolemic hemodilution with 1 L of lactated Ringer's solution, 13 patients were randomly assigned to receive, within 30 min, 3 mL/kg of either HBOC-201 or 6% hydroxyethyl starch (HES). Monitored variables included invasive arterial and pulmonary artery pressures, arterial and mixed venous blood gases, and calculations of cardiac index (CI), systemic and pulmonary vascular resistance indices, oxygen delivery index (DO2I), oxygen consumption index (VO2I), and oxygen extraction ratio (O2ER). Thirty minutes after HBOC-201 infusion, mean arterial pressure, systemic vascular resistance index, and CI were 149% (P = 0.028), 169% (P = 0.046), and 75% (P = 0.46) of the preinfusion values, respectively. No significant changes were noticed in heart rate and pulmonary vascular resistance index. DO2I and VO2I, 30 min after the infusion of HBOC-201, were 79% (P = 0.046) and 76% (P = 0.028) of the preinfusion values, respectively, whereas CaO2 and O2ER remained unaffected. We conclude that HBOC-201, at a dose of 3 mL/kg, impairs oxygen delivery because of adverse effects on cardiac output.
S M Kasper; M Walter; F Grüne; A Bischoff; H Erasmi; W Buzello
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  83     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-7     Citation Subset:  AIM; IM    
Department of Anesthesiology, University of Cologne, Germany.
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MeSH Terms
Aorta, Abdominal / surgery*
Blood Pressure / drug effects
Blood Substitutes / therapeutic use*
Blood Volume
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Hemoglobins / therapeutic use*
Hetastarch / therapeutic use
Isotonic Solutions
Middle Aged
Oxygen / blood
Oxygen Consumption / drug effects*
Pilot Projects
Preoperative Care
Surgical Procedures, Elective
Vascular Resistance / drug effects
Reg. No./Substance:
0/Blood Substitutes; 0/HBOC 201; 0/Hemoglobins; 0/Isotonic Solutions; 7782-44-7/Oxygen; 8022-63-7/Ringer's lactate; 9005-27-0/Hetastarch

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