Document Detail


Effects of helium on high frequency jet ventilation in model of airway stenosis.
MedLine Citation:
PMID:  16143576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The addition of helium to the inspired gas may facilitate ventilation in the presence of clinically evident upper airway obstruction. However, there are no data on the effects of using a helium-oxygen mixture during high frequency jet ventilation (HFJV) in upper airway obstruction. METHODS: HFJV at a frequency of 150 min(-1) (driving pressure 2 bar, inspiratory time 30%) was applied to a trachea-lung model to simulate ventilation through varying degrees of fixed laryngotracheal stenosis (2.5-8.5 mm). HFJV was delivered from above, through and below the level of stenosis to simulate supraglottic, transglottic and infraglottic administration. Measurements of distal tracheal pressures were repeated for each route at steady state for each stenosis diameter using both 100% oxygen and helium-oxygen (50% oxygen, 50% helium). The output of the ventilator was measured during operation on oxygen and helium-oxygen. RESULTS: Peak, mean and end-expiratory pressures were greater during simulated supraglottic HFJV than during transglottic and infraglottic HFJV, and pressures increased markedly as the diameter of the stenosis decreased for all routes of ventilation (P<0.001). Generated pressures during HFJV using helium-oxygen and 100% oxygen were very similar overall, although reductions in pressures were observed during ventilation with helium-oxygen via the transglottic and transtracheal routes at stenosis diameters <4 mm (P<0.05). However, HFJV with the helium-oxygen mixture increased the delivered gas volumes by approximately 18%. CONCLUSIONS: Using 50% helium-oxygen during HFJV in the presence of airway stenosis allows an 18% increase in minute volume at generated airway pressures which are the same as or lower than those when using 100% oxygen.
Authors:
P W Buczkowski; F N Fombon; W C Russell; J P Thompson
Related Documents :
24782556 - Noninvasive ventilation in severe acute asthma.
22019406 - New type of pressurized cultivation method providing oxygen for piezotolerant yeast.
16205326 - Evidence for myocardial defects under extreme acute normovolemic hemodilution with hydr...
21962236 - Cardiac and vascular structure and function parameters do not improve with alternate ni...
24306156 - Prevalence of elevated blood pressure and its relationship with fat mass, body mass ind...
1638726 - Pleural effusion as a cause of right ventricular diastolic collapse.
Publication Detail:
Type:  Journal Article     Date:  2005-09-02
Journal Detail:
Title:  British journal of anaesthesia     Volume:  95     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-10     Completed Date:  2005-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  701-5     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia, Critical Care and Pain Management, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester LE1 5WW, UK. piotrbuczkowski@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Air Pressure
Airway Obstruction / etiology,  therapy*
Helium / therapeutic use*
High-Frequency Jet Ventilation / methods*
Humans
Laryngostenosis / complications,  pathology
Models, Anatomic
Oxygen / therapeutic use
Tracheal Stenosis / complications,  pathology
Chemical
Reg. No./Substance:
7440-59-7/Helium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pre-oxygenation in the obese patient: effects of position on tolerance to apnoea.
Next Document:  Late preconditioning with isoflurane in cultured rat cortical neurones.