Document Detail

Effects of heavy particle irradiation and diet on amphetamine- and lithium chloride-induced taste avoidance learning in rats.
MedLine Citation:
PMID:  12384235     Owner:  NLM     Status:  MEDLINE    
Rats were maintained on diets containing either 2% blueberry or strawberry extract or a control diet for 8 weeks prior to being exposed to 1.5 Gy of 56Fe particles in the Alternating Gradient Synchrotron at Brookhaven National Laboratory. Three days following irradiation, the rats were tested for the effects of irradiation on the acquisition of an amphetamine- or lithium chloride-induced (LiCl) conditioned taste avoidance (CTA). The rats maintained on the control diet failed to show the acquisition of a CTA following injection of amphetamine. In contrast, the rats maintained on antioxidant diets (strawberry or blueberry extract) continued to show the development of an amphetamine-induced CTA following exposure to 56Fe particles. Neither irradiation nor diet had an effect on the acquisition of a LiCl-induced CTA. The results are interpreted as indicating that oxidative stress following exposure to 56Fe particles may be responsible for the disruption of the dopamine-mediated amphetamine-induced CTA in rats fed control diets; and that a reduction in oxidative stress produced by the antioxidant diets functions to reinstate the dopamine-mediated CTA. The failure of either irradiation or diet to influence LiCl-induced responding suggests that oxidative stress may not be involved in CTA learning following injection of LiCl.
Bernard M Rabin; Barbara Shukitt-Hale; Aleksandra Szprengiel; James A Joseph
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  953     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-17     Completed Date:  2003-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM; S    
Department of Psychology, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
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MeSH Terms
Amphetamine / pharmacology*
Antimanic Agents / pharmacology*
Antioxidants / pharmacology
Avoidance Learning / drug effects,  radiation effects*
Central Nervous System Stimulants / pharmacology*
Conditioning (Psychology) / drug effects,  radiation effects
Heavy Ions*
Lithium Chloride / pharmacology*
Oxidative Stress / drug effects,  radiation effects
Rats, Sprague-Dawley
Reg. No./Substance:
0/Antimanic Agents; 0/Antioxidants; 0/Central Nervous System Stimulants; 300-62-9/Amphetamine; 7439-89-6/Iron; 7447-41-8/Lithium Chloride
B M Rabin / U MD, Baltimore

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