Document Detail

Effects of heavy metals on mitogen-activated protein kinase pathways.
MedLine Citation:
PMID:  21432337     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The signaling pathways leading to cellular protection or cell death following exposure to heavy metals have not been fully clarified. Mitogen-activated protein kinases (MAPKs), i.e., extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase (JNK) and p38 MAPK transmit extracellular signals into the nucleus, and have been shown to participate in a diverse array of cellular functions such as cell growth, differentiation and apoptosis. Treatment with cadmium, inorganic mercury or tributyltin can activate ERK, JNK and p38 MAPK, and induces the expression of c-fos and c-jun genes prior to the development of apoptosis. However, the members of the MAPK family appear to be differentially activated depending on the heavy metal and the cell type exposed. Consequently, various cellular responses may be caused by the distinct pattern of MAPKs activation. MAPKs may be one of the important cellular signal transduction pathways affected by various environmental pollutants, including heavy metals.
Masato Matsuoka; Hideki Igisu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health and preventive medicine     Volume:  6     ISSN:  1342-078X     ISO Abbreviation:  Environ Health Prev Med     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2011-03-24     Completed Date:  2012-10-02     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  9609642     Medline TA:  Environ Health Prev Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  210-7     Citation Subset:  -    
Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan,
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