Document Detail

Effects of heat treatment of cow's milk and whey on the nutritional quality and antigenic properties.
MedLine Citation:
PMID:  6983327     Owner:  NLM     Status:  MEDLINE    
Recent experiments in guinea-pigs suggest that heat treatment applied during the manufacture of baby milk formulae reduces the immunological sensitising capacity of the cow's milk proteins. This immunological benefit must be weighed against possible damage that heat treatment may cause to the nutritional quality of the products. Severe heat treatment of skimmed milk (121 degrees C for 20 min) destroyed all the vitamin B12, about 60% of the thiamin and vitamin B6, 70% of the ascorbic acid, and about 30% of the folate. Available lysine was reduced by 21% and lactulose was formed (166 mg/100 ml). Despite extensive denaturation of the whey proteins the milk retained its capacity to sensitize guinea-pigs for systemic anaphylaxis when administered orally. Animals drinking heated milk also produced circulating antibodies to beta-lactoglobulin and casein, although titres were lower than for unheated milk. Unlike skimmed milk, heat-treated diafiltered whey failed to sensitize guinea-pigs orally. It caused the production of trace levels of antibodies in some of the animals, but these were specific for residual casein. We suggest that it may be possible to produce a non-sensitising baby milk without casein based on heat-denatured whey. The nutritional quality could be preserved by removing low molecular weight nutrients before heat treatment and adding back appropriate quantities later.
P J Kilshaw; L M Heppell; J E Ford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  57     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  842-7     Citation Subset:  AIM; IM    
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MeSH Terms
Antigens / immunology
Dairy Products*
Guinea Pigs
Hot Temperature*
Immunoglobulin G / biosynthesis
Lactose* / immunology
Milk* / immunology
Milk Proteins / immunology
Nutritive Value*
Passive Cutaneous Anaphylaxis
Protein Denaturation
Reg. No./Substance:
0/Antigens; 0/Immunoglobulin G; 0/Milk Proteins; 63-42-3/Lactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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