| Effects of heat treatment of cow's milk and whey on the nutritional quality and antigenic properties. | |
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MedLine Citation:
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PMID: 6983327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent experiments in guinea-pigs suggest that heat treatment applied during the manufacture of baby milk formulae reduces the immunological sensitising capacity of the cow's milk proteins. This immunological benefit must be weighed against possible damage that heat treatment may cause to the nutritional quality of the products. Severe heat treatment of skimmed milk (121 degrees C for 20 min) destroyed all the vitamin B12, about 60% of the thiamin and vitamin B6, 70% of the ascorbic acid, and about 30% of the folate. Available lysine was reduced by 21% and lactulose was formed (166 mg/100 ml). Despite extensive denaturation of the whey proteins the milk retained its capacity to sensitize guinea-pigs for systemic anaphylaxis when administered orally. Animals drinking heated milk also produced circulating antibodies to beta-lactoglobulin and casein, although titres were lower than for unheated milk. Unlike skimmed milk, heat-treated diafiltered whey failed to sensitize guinea-pigs orally. It caused the production of trace levels of antibodies in some of the animals, but these were specific for residual casein. We suggest that it may be possible to produce a non-sensitising baby milk without casein based on heat-denatured whey. The nutritional quality could be preserved by removing low molecular weight nutrients before heat treatment and adding back appropriate quantities later. |
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Authors:
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P J Kilshaw; L M Heppell; J E Ford |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of disease in childhood Volume: 57 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1983-01-19 Completed Date: 1983-01-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 842-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens / immunology Cattle Dairy Products* Guinea Pigs Hot Temperature* Immunoglobulin G / biosynthesis Lactose* / immunology Male Milk* / immunology Milk Proteins / immunology Nutritive Value* Passive Cutaneous Anaphylaxis Protein Denaturation |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Immunoglobulin G; 0/Milk Proteins; 63-42-3/Lactose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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