| Effects of halothane and enflurane on right ventricular performance in hearts of dogs anesthetized with pentobarbital sodium. | |
| | |
MedLine Citation:
|
PMID: 6848018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of enflurane and halothane on contractile force of the right ventricle were compared using the Walton-Brodie strain gage arch and pulmonary artery catheter data in dogs anesthetized with pentobarbital. Twenty mongrel dogs were studied to determine the effects of the two anesthetics on contractile force during a 30-minute exposure to four approximate multiples of MAC: 0.75, 1.0, 1.25, and 2.0, and during a 2-h exposure to 1.0 MAC of each agent. Both anesthetics caused a dose-dependent reduction in contractile force, cardiac output, and mean arterial blood pressure. Enflurane caused greater depression of all variables at all concentrations tested. After a 30-min exposure to 0.75, 1.0, 1.25, and 2.0 MAC, halothane depressed contractile force 33.9%, 37.9%, 46.1%, and 73.4%, respectively, and enflurane depressed contractile force 48.4%, 53.5%, 66.6%, and 81.3%, respectively. The depression produced by enflurane at 1.0 and 1.25 MAC was significantly greater (P less than 0.05) than the depression produced by halothane at equal MAC. The reduction of cardiac output by enflurane at 1.25 and 2.0 MAC was significantly greater than that observed with halothane (P less than 0.05). The decrease in mean blood pressure produced by enflurane was significantly greater (P less than 0.05) than the decrease produced by halothane at 1.0, 1.25, and 2.0 MAC. No significant differences between groups were found in temperature, arterial PCO2, PO2, pH, or hematocrit levels. No diminution of the differences in effect on contractility between the two agents was observed when the exposure period was lengthened to two hours at 1.0 MAC. |
| | |
Authors:
|
P S Mote; J K Pruett; Z W Gramling |
Related Documents
:
|
7595688 - Stabilization of the neuromuscular response when switching between different modes of n... 11576048 - Effects of remifentanil/propofol in comparison with isoflurane on dynamic cerebrovascul... 10653498 - Perioperative stress response in the dog: effect of pre-emptive administration of medet... 11094598 - Effect of remifentanil compared with fentanyl on intraocular pressure after succinylcho... 8589778 - Response of total and regional lean tissue and skeletal muscle to a program of energy r... 11152828 - A new coronary artery disease index of treadmill exercise electrocardiograms based on t... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Anesthesiology Volume: 58 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1983 Jan |
Date Detail:
|
Created Date: 1983-01-27 Completed Date: 1983-01-27 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 53-60 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, General* Animals Blood Pressure / drug effects Dogs Dose-Response Relationship, Drug Enflurane / pharmacology* Female Halothane / pharmacology* Hemodynamics / drug effects Male Myocardial Contraction / drug effects* Pentobarbital / pharmacology |
| Chemical | |
Reg. No./Substance:
|
13838-16-9/Enflurane; 151-67-7/Halothane; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of halothane anesthesia compared with fentanyl anesthesia and no anesthesia during coronary ...
Next Document: Profound arterial hypotension in dogs: brain electrical activity and organ integrity.