Document Detail


Effects of halothane and enflurane on right ventricular performance in hearts of dogs anesthetized with pentobarbital sodium.
MedLine Citation:
PMID:  6848018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of enflurane and halothane on contractile force of the right ventricle were compared using the Walton-Brodie strain gage arch and pulmonary artery catheter data in dogs anesthetized with pentobarbital. Twenty mongrel dogs were studied to determine the effects of the two anesthetics on contractile force during a 30-minute exposure to four approximate multiples of MAC: 0.75, 1.0, 1.25, and 2.0, and during a 2-h exposure to 1.0 MAC of each agent. Both anesthetics caused a dose-dependent reduction in contractile force, cardiac output, and mean arterial blood pressure. Enflurane caused greater depression of all variables at all concentrations tested. After a 30-min exposure to 0.75, 1.0, 1.25, and 2.0 MAC, halothane depressed contractile force 33.9%, 37.9%, 46.1%, and 73.4%, respectively, and enflurane depressed contractile force 48.4%, 53.5%, 66.6%, and 81.3%, respectively. The depression produced by enflurane at 1.0 and 1.25 MAC was significantly greater (P less than 0.05) than the depression produced by halothane at equal MAC. The reduction of cardiac output by enflurane at 1.25 and 2.0 MAC was significantly greater than that observed with halothane (P less than 0.05). The decrease in mean blood pressure produced by enflurane was significantly greater (P less than 0.05) than the decrease produced by halothane at 1.0, 1.25, and 2.0 MAC. No significant differences between groups were found in temperature, arterial PCO2, PO2, pH, or hematocrit levels. No diminution of the differences in effect on contractility between the two agents was observed when the exposure period was lengthened to two hours at 1.0 MAC.
Authors:
P S Mote; J K Pruett; Z W Gramling
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  58     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General*
Animals
Blood Pressure / drug effects
Dogs
Dose-Response Relationship, Drug
Enflurane / pharmacology*
Female
Halothane / pharmacology*
Hemodynamics / drug effects
Male
Myocardial Contraction / drug effects*
Pentobarbital / pharmacology
Chemical
Reg. No./Substance:
13838-16-9/Enflurane; 151-67-7/Halothane; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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