Document Detail


Effects of halothane, enflurane, and isoflurane on hypoxic pulmonary vasoconstriction in rat lungs in vitro.
MedLine Citation:
PMID:  6703386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rat lungs were ventilated and perfused at a constant rate in vitro. The maximal hypoxic pulmonary vasoconstrictor (HPV) response was recorded by measuring the pulmonary artery pressure change when the inspired oxygen concentration was changed from 21% to 3% (with 5.5% carbon dioxide) in the absence of anesthetic vapor. In different experimental groups, the effects of halothane, enflurane, and isoflurane on HPV were examined. In random order the anesthetics were added to the inspired gas in concentrations of 0.25, 0.5, 1, 1.5, and 2 or 2.5 MAC units. The HPV pressor response to 3% oxygen in the presence of anesthetic agent was expressed as a per cent of the pressure response observed in the absence of anesthetic (R%MAX). All three agents depressed HPV in a dose-related manner. The concentrations in MAC units at which 50% depression of HPV (ED50) occurred was 0.47, 0.60, and 0.56 for halothane, isoflurane, and enflurane, respectively, and neither the ED50 values nor the slopes of these dose response curves were significantly different. It was concluded that these halogenated general anesthetics inhibit HPV with essentially the same potency.
Authors:
C Marshall; L Lindgren; B E Marshall
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  60     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-04-17     Completed Date:  1984-04-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Depression, Chemical
Dose-Response Relationship, Drug
Enflurane / pharmacology*
Female
Halothane / pharmacology*
Isoflurane / pharmacology*
Methyl Ethers / pharmacology*
Oxygen / blood
Pulmonary Artery / physiology*
Rats
Rats, Inbred Strains
Vasoconstriction / drug effects*
Grant Support
ID/Acronym/Agency:
GM29628/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Methyl Ethers; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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