Document Detail


Effects of haloperidol on cholinergic striatal interneurons: relationship to oral dyskinesias.
MedLine Citation:
PMID:  15254795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a subset of rats, typical antipsychotic drugs (tAPD) produce oral dyskinesias called vacuous chewing movements (VCMs) that resemble tardive dyskinesia (TD), a behavioral side effect seen in a subset of people following tAPD treatment. Morphological changes within the striatum following tAPD have been correlated to VCMs in animal models. The cholinergic system has been implicated in expression of TD. To test the hypothesis that the striatal cholinergic system is perturbed after haloperidol treatment, rats were administered haloperidol for three weeks and tested for VCMs; the striata were then processed for the immunocytochemical localization of choline-acetyltransferase (ChAT). Neuronal density measures of ChAT-labeled neurons showed a 22% decrease in haloperidol-treated versus controls rats and a 37% reduction in the lateral portion of the striatum only in rats with VCMs. These findings further support evidence of the possible involvement of the cholinergic system and the ventrolateral striatum in VCMs, and possibly TD.
Authors:
J J Kelley; R C Roberts
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-04-02
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  111     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-15     Completed Date:  2004-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1075-91     Citation Subset:  IM    
Affiliation:
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. jkelley@umaryland.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antipsychotic Agents / pharmacology*
Behavior, Animal / drug effects
Cell Count
Choline O-Acetyltransferase / metabolism
Dyskinesia, Drug-Induced / enzymology,  physiopathology*
Haloperidol / pharmacology*
Interneurons / drug effects*,  enzymology
Neostriatum / cytology,  drug effects*,  enzymology
Parasympathetic Nervous System / drug effects,  enzymology,  metabolism*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
MH53494/MH/NIMH NIH HHS; MH60744/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 52-86-8/Haloperidol; EC 2.3.1.6/Choline O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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