Document Detail

Effects of half the tidal volume during cardiopulmonary resuscitation on acid-base balance and haemodynamics in pigs.
MedLine Citation:
PMID:  9846246     Owner:  NLM     Status:  MEDLINE    
The effects of half the tidal volume during cardiopulmonary resuscitation (CPR) on haemodynamics, acid-base balance, and oxygenation were studied in anaesthetized pigs. The animals were ventilated with a mean tidal volume of 12.5 +/- 0.5 ml/kg at a rate of 14/minute resulting in a mean arterial pCO2 of 40 +/- 3 mmHg. They were randomly assigned to two groups: in one group ventilation was performed with half the pre-arrest tidal volume (50% group; n = 9), in the other group ventilation remained unchanged during CPR (100% group; n = 10). After 8 minutes of CPR attempts were made to restore spontaneous circulation with epinephrine and countershocks. There were no differences in advanced life support requirements, haemodynamic parameters, and resuscitability between the two groups. During CPR up to 5 minutes after restoration of spontaneous circulation (ROSC) dead space ventilation was significantly higher in the 50% group compared with the 100% group (p < 0.05). During CPR (at 3 and 7 minutes) arterial pO2 values were significantly lower (218 +/- 136 and 221 +/- 120 mmHg vs. 381 +/- 130 and 352 +/- 147 mmHg; FiO2 1.0) and hyperventilation was less pronounced (34.4 +/- 7.3 and 31.3 +/- 7.7 mmHg vs. 26.2 +/- 5.6 and 26.9 +/- 6.3 mmHg) in the 50% group. Our results suggest that half the tidal volume during CPR is likely to establish a more physiological acid-base balance and has no adverse effects on haemodynamics in intubated pigs ventilated with pure oxygen.
M Winkler; W Mauritz; W Hackl; H Gilly; M Weindlmayr-Goettel; K Steinbereithner; I Schindler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of emergency medicine : official journal of the European Society for Emergency Medicine     Volume:  5     ISSN:  0969-9546     ISO Abbreviation:  Eur J Emerg Med     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1999-03-05     Completed Date:  1999-03-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442482     Medline TA:  Eur J Emerg Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Ludwig Boltzmann Institute of Experimental Anaesthesia and Research in Intensive Care Medicine, Vienna, Austria.
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MeSH Terms
Acid-Base Equilibrium*
Cardiopulmonary Resuscitation*
Random Allocation
Respiration, Artificial*
Tidal Volume*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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