| Effects of haemorrhagic hypotension on the subcapsular artery and microvasculature of the rat testis. | |
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MedLine Citation:
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PMID: 16524367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Developing germ cells may be sensitive to even moderate reductions in blood flow. Surprisingly, however, experimental evidence suggests that the rat testis may be unable to maintain its blood flow during a decrease in systemic blood pressure. This study was therefore performed in order to answer the following questions: Is the testis able to maintain its blood flow during moderate to major reductions in blood pressure and, if so, at which level of the testicular vasculature (main artery or microcirculation) does this compensatory response take place? Moderate (-20%) and major (-40%) reductions in blood pressure were induced in anaesthetized rats by haemorrhage and the effects on testicular microvascular blood flow and subcapsular testicular artery diameter were examined by using laser Doppler flowmetry and in vivo video-microscopy respectively. Haemorrhagic hypotension led to decreased local testicular blood flow, but the relative reductions in flow were generally only half as large as the reductions in blood pressure. Hypotension also decreased the diameter of the main subcapsular testicular artery. During large reductions in blood pressure the subcapsular testicular artery constricts and testicular blood flow decreases. However, blood flow is reduced proportionally less than the mean arterial pressure, suggesting that local regulatory mechanisms are present in the testicular microvasculature, which may prevent blood flow from falling below a critical level. |
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Authors:
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E Lissbrant; O Collin; J-E Damber; A Bergh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-08 |
Journal Detail:
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Title: International journal of andrology Volume: 29 ISSN: 0105-6263 ISO Abbreviation: Int. J. Androl. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-15 Completed Date: 2006-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8000141 Medline TA: Int J Androl Country: England |
Other Details:
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Languages: eng Pagination: 434-40 Citation Subset: IM |
Affiliation:
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Department of Medical Biosciences, Umeå University, Umeå, Sweden. erik.lissbrant@vgregion.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology Animals Arteries / physiopathology Blood Pressure Hemorrhage / complications, physiopathology* Hypotension / etiology, physiopathology* Laser-Doppler Flowmetry Male Microcirculation / physiology Microscopy, Video Rats Rats, Sprague-Dawley Regional Blood Flow / physiology Testis / blood supply*, physiopathology* Vasodilation / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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