Document Detail

Effects of guanadrel on patients with thyrotoxicosis.
MedLine Citation:
PMID:  580863     Owner:  NLM     Status:  MEDLINE    
Eleven patients with Graves' disease were treated with guanadrel sulfate and observed for changes in neuromuscular and cardiovascular manifestations. No notable changes in pulse rate or muscle strength were detected in either these patients during a three-day pretreatment period or in five control patients with Graves' disease receiving placebo for six days. Thyroid hormone levels were not altered by seven days of guanadrel sulfate therapy (5 to 20 mg orally every six hours), and no adverse side effects were encountered. Mean supine resting pulse fell from 102 +/- 6 (mean +/- SEM) to 90 +/- 3 beats per minute (P less than .02). The patients' proximal and distal muscle strengths were initially decreased, when compared with healthy subjects, and improved substantially with guanadrel therapy. We conclude that guanadrel sulfate may be useful in the symptomatic management of patients with thyrotoxicosis.
S Rubenfeld; B M Patten; P O Kohler
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  138     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-08-28     Completed Date:  1978-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1106-8     Citation Subset:  AIM; IM    
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MeSH Terms
Drug Evaluation
Graves Disease / drug therapy*
Guanidines / therapeutic use*
Middle Aged
Muscles / drug effects
Pulse / drug effects
Spiro Compounds / therapeutic use
Reg. No./Substance:
0/Guanidines; 0/Spiro Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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