| Effects of growth hormone releasing hormone on insulin action and insulin secretion in a hypopituitary patient evaluated by the clamp technique. | |
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MedLine Citation:
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PMID: 1519429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of growth hormone releasing hormone (GHRH-44) therapy on insulin action and secretion was evaluated in a hypopituitary patient after one month and one year of treatment. Hepatic and peripheral insulin action was studied with the hyperinsulinemic-euglycemic clamp in combination with [6,6-2H2]glucose tracer infusion. First and second phase insulin secretion was assessed with the hyperglycemic clamp. Prior to GHRH-44 therapy the hypopituitary patient had higher insulin mediated glucose disposal rate and lower basal and stimulated insulin concentrations by more than two standard deviations from the mean of a control group. Following therapy there was no change in basal hepatic glucose production; however, there was evidence of diminished peripheral insulin action. This was manifested by decreased insulin mediated glucose disposal during the hyperinsulinemic-euglycemic clamp, and increased insulin secretion during the hyperglycemic clamp. We conclude that GHRH-44 therapy in this patient was associated with decreased peripheral insulin action which was compensated for by increased insulin secretion. |
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Authors:
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S Arslanian; S Kalhan |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Acta endocrinologica Volume: 127 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-10-08 Completed Date: 1992-10-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 93-6 Citation Subset: IM |
Affiliation:
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Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital, University of Pittsburgh, PA 15213. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Female Glucose Clamp Technique Growth Hormone-Releasing Hormone / pharmacology*, therapeutic use Humans Hypopituitarism / blood*, drug therapy, physiopathology* Insulin / blood*, physiology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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5 MO1-RR00086-25/RR/NCRR NIH HHS; P-50-HD11089/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 9034-39-3/Growth Hormone-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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