| Effects of growth hormone on leucine absorption, intestinal morphology, and ultrastructure of the goldish intestine. | |
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MedLine Citation:
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PMID: 15644934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms whereby exogenous growth hormone modulates intestinal structure and function in fish were investigated. Goldfish (Carassius auratus) were fed commercial flake diet sprayed with recombinant carp growth hormone (cGH) daily for 1 month. Control animals received food sprayed with the vehicle. After 1 month of daily feedings, body mass and length were determined, and animals were sacrificed to study intestinal characteristics. Sections of foregut were removed after determination of total gut length for measurement of leucine uptake, histology, and epithelial ultrastructure. Oral administration of cGH for 1 month resulted in a 40% increase in body mass and an 8% increase in body length above controls. Gut length was 43% greater and the gut length to body length ratio was 32% greater as a result of the cGH treatment. Feeding with cGH also resulted in a significant increase in leucine uptake and increased gut mucosal thickness. Analysis of transmission electron micrographs revealed significant increases in the microvillous height and density and epithelial surface area. The findings indicate that growth hormone added to feed may increase growth in fish, in part by significantly increasing gut length, mucosal thickness, and epithelial brush border surface area, leading to enhanced epithelial absorption. |
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Authors:
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R L Walker; A G Buret; C L Jackson; K G-E Scott; R Bajwa; H R Habibi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 82 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2005-01-12 Completed Date: 2005-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: Canada |
Other Details:
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Languages: eng Pagination: 951-9 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of Calgary, AB, Canada. rlwalker@ucalgary.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Goldfish / growth & development, metabolism* Growth Hormone / pharmacology* Intestinal Absorption / drug effects*, physiology Intestinal Mucosa / drug effects, growth & development, metabolism, ultrastructure* Intestines / anatomy & histology*, growth & development, metabolism, physiology Leucine / metabolism* |
| Chemical | |
Reg. No./Substance:
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61-90-5/Leucine; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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