Document Detail

Effects of growth hormone and insulin-like growth factor I in experimental heart failure.
MedLine Citation:
PMID:  10990154     Owner:  NLM     Status:  MEDLINE    
These studies suggest that IGF-I and GH have generally favourable effects on the failing heart. They further demonstrate the ability of the severely depressed and failing heart to respond to the trophic and inotropic effects of GH. There is, however, a need for a better understanding of the mechanism of the contractility effect, the character of the hypertrophy observed (whether it is a more favourable type than that secondary to mechanical overload) and the vascular actions, both trophic and vasodilatory. In addition, the degree to which high-dose ACE inhibition or angiotensin II receptor blockade may inhibit some of these effects requires further study. Finally, it is clear that additional experimental studies and clinical trials are needed to investigate the long-term effects of GH on morbidity and mortality in heart failure, as well as the possible side-effects and other actions, such as the potential of GH to enhance skeletal muscle size and strength.
J Ross; T Ryoke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  8 Suppl B     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  2000-10-04     Completed Date:  2000-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  159-61     Citation Subset:  IM    
Department of Medicine, University of California at San Diego, La Jolla 92093-0613, USA.
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MeSH Terms
Cardiac Output / drug effects
Cardiomyopathy, Dilated / drug therapy,  physiopathology
Disease Models, Animal
Growth Hormone / pharmacology,  therapeutic use*
Heart / drug effects,  physiopathology
Heart Failure / drug therapy*,  physiopathology*
Insulin-Like Growth Factor I / pharmacology,  therapeutic use*
Myocardial Contraction / drug effects
Grant Support
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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