Document Detail

Effects of gray and white mineral trioxide aggregate on the proliferation of oral keratinocytes and cementoblasts.
MedLine Citation:
PMID:  16500228     Owner:  NLM     Status:  MEDLINE    
Mineral trioxide aggregate (MTA) is used as a repair material and may directly contact cells from different cell lineages. The purpose of this study was to assess cell proliferation of immortalized Murine cementoblasts (OCCM.30) and immortalized keratinocytes (OKF6/TERT1) on gray MTA (GMTA) and white MTA (WMTA) with the DNA intercalating dye Hoechst 33342. Cells were grown for 72 hours on GMTA or WMTA that had been cured for 24 hours or 12 days. WMTA significantly (p < 0.001) increased the proliferation of OCCM.30 cementoblasts compared to control and OKF6/TERT1 keratinocytes. Both cell types grew significantly (p < 0.001) better on the surface of WMTA compared to GMTA. In addition, both cell types showed significantly (p < 0.005) higher proliferation when grown on 12-day-cured GMTA compared to 24-hour-cured GMTA.
Tiina Oviir; Dustin Pagoria; Gabriela Ibarra; Werner Geurtsen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endodontics     Volume:  32     ISSN:  0099-2399     ISO Abbreviation:  J Endod     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-3     Citation Subset:  D    
Department of Endodontics, University of Washington, WA 98195-7456, USA.
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MeSH Terms
Aluminum Compounds / pharmacology*
Benzimidazoles / diagnostic use
Calcium Compounds / pharmacology*
Cell Line, Transformed
Cell Proliferation / drug effects*
Dental Cementum / cytology*
Drug Combinations
Fluorescent Dyes / diagnostic use
Keratinocytes / cytology*
Oxides / pharmacology*
Root Canal Filling Materials / pharmacology*
Silicates / pharmacology*
Time Factors
Reg. No./Substance:
0/Aluminum Compounds; 0/Benzimidazoles; 0/Calcium Compounds; 0/Drug Combinations; 0/Fluorescent Dyes; 0/Oxides; 0/Root Canal Filling Materials; 0/Silicates; 0/mineral trioxide aggregate; 23491-52-3/HOE 33342

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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