Document Detail


Effects of grandmothers' smoking in pregnancy on birth weight: intergenerational cohort study.
MedLine Citation:
PMID:  14563745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the influences on birth weight of maternal smoking during pregnancy across generations.
DESIGN: Intergenerational cohort study.
PARTICIPANTS: Members of the 1958 birth cohort and their offspring and mothers.
SETTING: England, Scotland, and Wales.
MAIN OUTCOME MEASURE: Birth weight.
RESULTS: Information on grandmothers' smoking during pregnancy was available for 9028 singleton offspring of 4302 female cohort members. Assuming heritable transmission through the intergenerational association, grandmothers' smoking was predicted to result in a 34 g reduction (95% confidence interval -41 g to -28 g) in the birth weight of grandchildren. Random effects models showed a negative association between grandmothers' smoking and birth weight of grandchildren (beta regression coefficient -24 g, -50 g to 3 g), but this effect was eliminated after adjustment for maternal smoking (0 g, -26 g to 26 g). No association was evident among the offspring of non-smoking mothers (n = 6105; 14 g, -17 g to 46 g), and after adjustment for maternal birth weight, adult height and body mass index, grandmothers' smoking was positively associated with the birth weight of grandchildren (45 g, 10 g to 80 g).
CONCLUSION: Deficits in mothers' birth weight attributable to their mother smoking was not evident in the grandchildren.
Authors:
Elina Hyppönen; George Davey Smith; Chris Power
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  327     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-17     Completed Date:  2003-11-06     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  898     Citation Subset:  AIM; IM    
Affiliation:
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH. e.hypponen@ich.ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight / genetics*
Cohort Studies
Confidence Intervals
Female
Gestational Age
Humans
Infant, Newborn
Linear Models
Mothers / statistics & numerical data*
Pedigree
Pregnancy
Prenatal Exposure Delayed Effects
Smoking / adverse effects*,  genetics
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