| Effects of graded reductions in internal mammary artery bypass flow on left ventricular function. | |
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MedLine Citation:
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PMID: 8267435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the controversial relationship between reduction in internal mammary artery (IMA) graft blood flow and left ventricular function in a canine model. Ten dogs underwent IMA grafting to the left anterior descending coronary artery. The left anterior descending coronary artery proximal to the IMA graft was intermittently occluded while IMA flow was mechanically controlled for 5-minute periods to produce four IMA flow groups representing 100%, 75%, 50%, and 25% of unoccluded IMA graft blood flow. As a control, the left ventricle was reperfused with native left anterior descending coronary artery flow between each IMA graft flow period to allow return to steady state. Sonomicrometry was used to obtain stroke work end-diastolic dimension relationship data for regional and global left ventricular function for each of the four flow groups. The global pressure recruitable work area relationship showed a significant rightward shift at 25% of unoccluded IMA flow, whereas the regional pressure recruitable work area relationship shifted at 50% of unoccluded IMA flow. Thus, regional myocardial function is more sensitive to reductions in IMA blood flow than is global left ventricular performance, and there is a significant IMA flow reserve for global left ventricular function. |
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Authors:
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L J Harris; G A Crooke; C L LaMendola; E A Grossi; F G Baumann; R A Esposito |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 56 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-01-25 Completed Date: 1994-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1348-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, New York University Medical Center, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Data Interpretation, Statistical Dogs Internal Mammary-Coronary Artery Anastomosis* Mammary Arteries / physiology* Reference Values Regional Blood Flow Ventricular Function, Left / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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