Document Detail


Effects of graded mechanical compression of rabbit sciatic nerve on nerve blood flow and electrophysiological properties.
MedLine Citation:
PMID:  20122834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Entrapment neuropathy is a frequent clinical problem that can be caused by, among other factors, mechanical compression; however, exactly how a compressive force affects the peripheral nerves remains poorly understood. In this study, using a rabbit model of sciatic nerve injury (n=12), we evaluated the time-course of changes in intraneural blood flow, compound nerve action potentials, and functioning of the blood-nerve barrier during graded mechanical compression. Nerve injury was applied using a compressor equipped with a custom-made pressure transducer. Cessation of intraneural blood flow was noted at a mean compressive force of 0.457+/-0.022 N (+/-SEM), and the compound action potential became zero at 0.486+/-0.031 N. Marked extravasation of Evans blue albumin was noted after 20 min of intraneural ischemia. The functional changes induced by compression are likely due to intraneural edema, which could subsequently result in impairment of nerve function. These changes may be critical factors in the development of symptoms associated with nerve compression.
Authors:
Takafumi Yayama; Shigeru Kobayashi; Yoshitaka Nakanishi; Kenzo Uchida; Yasuo Kokubo; Tsuyoshi Miyazaki; Kenichi Takeno; Kosuke Awara; Erisa S Mwaka; Yukihide Iwamoto; Hisatoshi Baba
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Publication Detail:
Type:  Journal Article     Date:  2010-02-01
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  501-5     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Matsuoka Shimoaizuki 23, Eiheiji, Fukui 910-1193, Japan. yayama@u-fukui.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Blood-Nerve Barrier / physiopathology
Electrophysiology
Microscopy, Fluorescence
Nerve Compression Syndromes / physiopathology*
Rabbits
Regional Blood Flow / physiology
Sciatic Nerve / blood supply*,  physiopathology
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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