Document Detail

Effects of graded amounts (0-50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults.
MedLine Citation:
PMID:  9440372     Owner:  NLM     Status:  MEDLINE    
Eight normolipidemic males ingested on separate days and in a random order five mixed meals containing 0, 15, 30, 40, or 50 g fat. Fasting and postprandial blood samples were obtained for 7 h and chylomicrons and lipoproteins were isolated. The nonfat and 15-g fat meals did not generate noticeable postprandial variations except for HDL phospholipids (P < 0.05). The serum and chylomicron triacylglycerol responses obtained after the meals correlated positively with the amount of fat ingested and peaked after 2-3 h. Serum free cholesterol and phospholipids increased and esterified cholesterol decreased postprandially in a dose-response manner. At the same time, triacylglycerol-rich-lipoprotein triacylglycerols, esterified cholesterol, LDL free cholesterol, HDL triacylglycerols, phospholipids, and free cholesterol increased whereas LDL and HDL esterified cholesterol decreased when the amount of ingested fat increased. The data showed that increasing the amount of fat in the usual range of ingestion (0-50 g) led to stepwise increases in the postprandial rise of chylomicron and serum triacylglycerols and induced marked changes in serum lipoproteins postprandially. The existence of a no-effect level of dietary fat (15 g) on postprandial lipemia and lipoproteins in healthy adults was shown.
C Dubois; G Beaumier; C Juhel; M Armand; H Portugal; A M Pauli; P Borel; C Latgé; D Lairon
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  67     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-09     Completed Date:  1998-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  AIM; IM    
Unité 130-INSERM (Institut National de la Santé et de la Recherche Médicale), Marseille, France.
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MeSH Terms
Cholesterol / blood,  classification,  metabolism
Chylomicrons / blood,  metabolism
Dietary Fats / administration & dosage,  adverse effects*
Insulin / blood,  metabolism
Linear Models
Lipid Metabolism
Lipids / blood*
Lipoproteins / blood*,  chemistry,  metabolism
Phospholipids / blood,  metabolism
Postprandial Period / physiology*
Time Factors
Triglycerides / blood,  metabolism
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Lipids; 0/Lipoproteins; 0/Phospholipids; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol

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