Document Detail

Effects of gonadotropin releasing hormone and estradiol on c-fos expression in the rat hippocampus.
MedLine Citation:
PMID:  19912764     Owner:  NLM     Status:  In-Data-Review    
The effects of ovariectomy, estradiol, and gonadotropin releasing hormone (GnRH) on the protein synthetic activity of hippocampal neurons were studied with immunohistochemistry for the proto-oncogene c-fos. Ovariectomy caused a reduction in the number of c-fos-positive neurons to 16% in area CA(1) and to 25% in area CA(3) when compared to that in the intact control animal. The dentate gyrus was only slightly affected. The decline in the number of c-fos-immunoreactive neurons in the Ammon's horn was partially reversed by a single intravenous injection of estradiol which resulted in the expression of c-fos in 71% of the neurons in area CA(1) and 74% in CA(3) when compared to the numbers of positive cells in the control animals. Similarly, intracerebroventricular injections of 10 muM GnRH caused an increase in the number of c-fos-positive cells to 68% in area CA(1) and to 52% in area CA(3) compared to that in the control animals. The induction of c-fos synthesis after estradiol and GnRH was transient and reached a maximum after 1 to 2 h before it declined to pretreatment levels after 8 h. The results suggest that both estradiol and GnRH exert specific effects on protein synthesis in certain neurons of the hippocampus and that these effects of the hormones are, at least in part, mediated by c-fos.
L Jennes
Related Documents :
8138374 - Induction of c-fos expression in the rostral medulla of rats following electroacupunctu...
10320024 - Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are a...
16626634 - Effects of spinal cord injury on c-fos expression in hypothalamic paraventricular nucle...
15985704 - Open field stress and neurons containing calcium-binding proteins in the piriform corte...
11370514 - The effects of stimulating the cerebellar nodulus in the cat on the responses of vestib...
9277634 - Transcranial magnetic stimulation-induced changes in eeg and responses recorded from th...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  1     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  2009-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  -    
Department of Anatomy, Wright State University Schoot of Medicine, Dayton, Ohio 45435, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Activation of Ca(2+)/calmodulin-dependent protein kinase II in cerebellar granule cells by N-methyl-...
Next Document:  Regulation of phospholipase D in astroglial cells by calcium-activated protein kinase C.