Document Detail

Effects of the gonadotropin-releasing hormone antagonist cetrorelix in the early postimplantation period on rat pregnancy.
MedLine Citation:
PMID:  21242023     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The effect of cetrorelix given in the early implantation period on rat pregnancy was investigated.
STUDY DESIGN: Forty-nine virgin Sprague-Dawley rats were randomized into six groups. At the 4th or 8th days of sperm plug, groups received 15, 75, 150 μg/kg cetrorelix or saline. Three subjects were randomly selected from each group and sacrificed at 11th gestational day for histomorphometric analysis. The remaining subjects were allowed to complete their pregnancy period. Volumes of total conceptus, labyrinth zone, transitional zone, giant cell zone, and exocoelomic cavity were calculated according to Cavalieri's principle.
RESULTS: Subjects receiving cetrorelix at 15 or 150 μg doses at the 4th day (D4) and those receiving cetrorelix at 150 μg dose at the 8th day (D8) of pregnancy delivered later than the controls. On necropsy examination at the 11th day, mean embryo weights of the cetrorelix 15 D4, 150 D4, 15 D8 and 75 D8 groups were found to be significantly lower than that of the controls (p<0.05). On histomorphometric evaluation, volumes of the fetuses and the amniotic sacs were decreased by cetrorelix at all doses studied dose dependently. Gross congenital anomalies were observed in the pups of three rats of the cetrorelix 150 D4 and D8 groups.
CONCLUSION: The results of this study suggest that cetrorelix in the early post-implantation period may lead to serious side effects in the rat.
Niyazi Tug; Unal Uslu; Alev Cumbul; Signem Eyuboglu; Cetin Cam; Ates Karateke; Bayram Yilmaz
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Publication Detail:
Type:  Journal Article     Date:  2011-01-15
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  155     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-25     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  166-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Yeditepe University, Faculty of Medicine, Istanbul, Turkey.
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MeSH Terms
Abnormalities, Drug-Induced / pathology
Amnion / drug effects,  pathology
Dose-Response Relationship, Drug
Embryonic Development / drug effects*
Genital Diseases, Female / drug therapy
Gestational Age
Giant Cells / drug effects,  pathology
Gonadotropin-Releasing Hormone / administration & dosage,  adverse effects,  analogs & derivatives*,  antagonists & inhibitors*
Hormone Antagonists / administration & dosage,  adverse effects*
Placenta / drug effects,  pathology
Random Allocation
Rats, Sprague-Dawley
Reg. No./Substance:
0/Hormone Antagonists; 33515-09-2/Gonadotropin-Releasing Hormone; OON1HFZ4BA/cetrorelix

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