| Effects of gonadotropin-releasing hormone (GnRH) on gastric secretion and gastrin release in the dog. | |
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MedLine Citation:
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PMID: 6132944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of GnRH on gastric secretion and gastrin release from dogs provided with gastric fistulae and Heidenhain pouches have been investigated. A transient yet significant inhibition of pentagastrin-stimulated secretion from gastric fistulae was observed, while secretion from Heidenhain pouches was unchanged. The maximal inhibitory effect of GnRH on both acid and pepsin secretion stimulated by 2-deoxy-D-glucose was obtained from gastric fistulae. On the contrary, GnRH failed to affect either acid secretion stimulated by bethanechol or acid secretion and gastrin release induced by bombesin. The present results indicate that GnRH possesses an inhibitory action on gastric secretion from the vagally innervated stomach of the dog. The most likely inhibitory mechanism seems to be represented by a decrease of the vagal activity. |
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Authors:
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G Soldani; M Del Tacca; G Bambini; A Polloni; C Bernardini; E Martinotti; E Martino |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 5 ISSN: 0391-4097 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 1982 Nov-Dec |
Date Detail:
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Created Date: 1983-06-10 Completed Date: 1983-06-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: ITALY |
Other Details:
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Languages: eng Pagination: 393-6 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bethanechol Bethanechol Compounds / pharmacology Bombesin / pharmacology Deoxyglucose / pharmacology Dogs Gastric Acid / secretion Gastric Mucosa / drug effects*, secretion Gastrins / secretion* Pentagastrin / pharmacology Pepsin A / secretion Pituitary Hormone-Releasing Hormones / pharmacology* Vagus Nerve / physiology |
| Chemical | |
Reg. No./Substance:
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0/Bethanechol Compounds; 0/Gastrins; 0/Pituitary Hormone-Releasing Hormones; 154-17-6/Deoxyglucose; 31362-50-2/Bombesin; 5534-95-2/Pentagastrin; 674-38-4/Bethanechol; EC 3.4.23.1/Pepsin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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