Document Detail


Effects of gonadotrophin-releasing hormone agonist on uterine fibroids and bone density.
MedLine Citation:
PMID:  2512467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bone density (BD) was evaluated by single photon absorptiometry (SPA) in 18 women treated with Buserelin a gonadotrophin-releasing hormone (LHRH) analogue, for uterine fibroids. Buserelin was administered for a period of 6 mth. Amenorrhoea and oestradiol levels in the follicular-phase range were recorded in all patients during treatment. Fibroid volume was evaluated by means of ultrasound. SPA was performed at the 1/3 proximal radius and at the 1/10 distal radius sites before starting therapy and every 2 mth subsequently for 12 mth. BD was also measured in a control group of 18 normally-menstruating premenopausal women, matched for age and body mass index. No significant changes in BD at the proximal or distal radius sites were observed in either the cases or the controls during the study. Moreover, comparison of the data on the cases and the controls revealed no differences in BD at 0, 6 or 12 mth. Thus, although LHRH analogue treatment proved effective in reducing fibroids, it did not cause any significant changes in BD.
Authors:
G Bianchi; S Costantini; P Anserini; G Rovetta; P Monteforte; M V Menada; L Fagà; L De Cecco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Maturitas     Volume:  11     ISSN:  0378-5122     ISO Abbreviation:  Maturitas     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-01-12     Completed Date:  1990-01-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  IM    
Affiliation:
Institute E. Bruzzone, Rheumatological Centre, University of Genoa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Density / drug effects*
Buserelin / pharmacology*,  therapeutic use
Estradiol / blood
Female
Humans
Leiomyoma / drug therapy*,  physiopathology
Middle Aged
Time Factors
Uterine Neoplasms / drug therapy*,  pathology
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 57982-77-1/Buserelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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