Document Detail


Effects of glycyl-glutamine dipeptide supplementation on myocardial damage and cardiac function in rats after severe burn injury.
MedLine Citation:
PMID:  23638213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glutamine decreases myocardial damage in ischemia/reperfusion injury. However, the cardioprotective effect of glutamine after burn injury remains unclear. Present study was to explore the protective effect of glycyl-glutamine dipeptide on myocardial damage in severe burn rats. Seventy-two Wistar rats were randomly divided into three groups: normal control (C), burned control (B) and glycyl-glutamine dipeptide-treated (GG) groups. B and GG groups were inflicted with 30% total body surface area of full thickness burn. The GG group was given 1.5 g/kg glycyl-glutamine dipeptide per day and the B group was given the same dose of alanine via intraperitoneal injection for 3 days. The serum CK, LDH, AST, and, blood lactic acid levels, as well as the myocardium ATP and GSH contents, were measured. The indices of cardiac contractile function and histopathological change were analyzed at 12, 24, 48, and 72 post-burn hours (PBH). The serum CK, LDH, AST and blood lactic acid levels increased, and the myocardium ATP and GSH content decreased in both burned groups. Compared with B group, the CK, LDH, AST and blood lactic acid levels reduced, myocardium ATP and GSH content increased in GG group. Moreover, the inhibition of cardiac contractile function and myocardial histopathological damage were reduced significantly in GG group. We conclude that myocardial histological structure and function were damaged significantly after burn injury, glycyl-glutamine dipeptide supplementation is beneficial to myocardial preservation by improving cardiocyte energy metabolism, increasing ATP and glutathione synthesis.
Authors:
Yong Zhang; Hong Yan; Shang-Gun Lv; Lin Wang; Guang-Ping Liang; Qian-Xue Wan; Xi Peng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-15
Journal Detail:
Title:  International journal of clinical and experimental pathology     Volume:  6     ISSN:  1936-2625     ISO Abbreviation:  Int J Clin Exp Pathol     Publication Date:  2013  
Date Detail:
Created Date:  2013-05-02     Completed Date:  2013-11-27     Revised Date:  2013-12-02    
Medline Journal Info:
Nlm Unique ID:  101480565     Medline TA:  Int J Clin Exp Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  821-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Burns / complications*,  metabolism,  physiopathology
Dipeptides / pharmacology*
Heart / drug effects*
Heart Function Tests
Male
Myocardial Ischemia / etiology
Myocardium / metabolism,  pathology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Dipeptides; 13115-71-4/glycylglutamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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