Document Detail


Effects of glycerol feeding before and after exhausting exercise in rats.
MedLine Citation:
PMID:  7009529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats were fed either 1 g of glycerol or 1 g of glucose following exercise to exhaustion. Glucose feeding resulted in a rapid increase in blood glucose, with attainment of peak hyperglycemia within 1 h and of peak muscle glycogen in about 2 h. Feeding 1 g of glycerol resulted in marked elevation of glycerol concentration in blood, liver, and muscle; the highest values, measured 1 h after glycerol feeding, ranged from 29 to 42 mumol/g tissue. Blood glucose and muscle glycogen increased slowly in the glycerol-fed rats and peaked much later than after glucose feeding. In perfused rat hindlimb muscles, negligible amounts of [14C]glycerol were incorporated into glycogen. These findings suggest that muscle is not able to utilize glycerol to a significant extent and that glucose derived from glycerol was the major substrate for muscle glycogen synthesis. Animals fed glycerol before a run to exhaustion were able to exercise significantly longer than control rats (153 +/- 11 min vs. 116 +/- 6 min). The glycerol-fed rats depleted their muscle and liver glycogen stores less rapidly than the controls and were protected against development of hypoglycemia during the exercise.
Authors:
S E Terblanche; R D Fell; A C Juhlin-Dannfelt; B W Craig; J O Holloszy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  50     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  94-101     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / analysis
Fatty Acids, Nonesterified / blood
Female
Glucagon / blood
Glucose / pharmacology
Glycerol / analysis,  pharmacology*
Glycogen / analysis
Insulin / blood
Lactates / analysis
Liver / analysis
Liver Glycogen / analysis
Male
Muscles / analysis
Physical Exertion / drug effects*
Rats
Time Factors
Grant Support
ID/Acronym/Agency:
1-FO-TWO 02603/TW/FIC NIH HHS; AM-07226/AM/NIADDK NIH HHS; AM-18986/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Lactates; 0/Liver Glycogen; 50-99-7/Glucose; 56-81-5/Glycerol; 9005-79-2/Glycogen; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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