Document Detail

Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome.
MedLine Citation:
PMID:  20504977     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epidemiologic studies suggest that diets with a low glycemic index (GI) or glycemic load (GL) are associated with a decreased risk of developing metabolic syndrome. Intervention studies are inconsistent, however, possibly due to differences in macronutrient and fiber compositions of the experimental diets.
OBJECTIVE: We tested side-by-side test foods with similar macronutrient and fiber compositions but with different sucrose-flour ratios or carbohydrate source to determine the effects of different GIs and GLs on metabolic risk markers in overweight subjects.
DESIGN: Overweight men (n = 9) and women (n = 6) received in random order for 11 wk 4 test foods with an increased GI or a decreased GI (69 compared with 40, 86 compared with 48, 63 compared with 37, and 51 compared with 20, respectively). There was a GL difference of 32 units between the 2 interventions.
RESULTS: At the end of the 11-wk intervention periods, the decreased GL test foods did not change fasting plasma glucose (mean +/- SD: 5.83 +/- 0.6 compared with 5.94 +/- 0.6 mmol/L) or insulin (8.3 +/- 2.8 compared with 9.8 +/- 5.1 mU/L) concentrations compared with increased GL test foods. Serum total cholesterol (5.56 +/- 0.90 compared with 5.76 +/- 1.04 mmol/L), LDL-cholesterol (3.57 +/- 0.72 compared with 3.68 +/- 0.80 mmol/L), HDL-cholesterol (1.21 +/- 0.38 compared with 1.24 +/- 0.37 mmol/L), and triacylglycerol (1.61 +/- 0.77 compared with 1.78 +/- 1.04 mmol/L) concentrations were also not significantly different for decreased and increased GL test foods, respectively. Finally, proinflammatory (high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, monocyte chemoattractant protein 1) and prothrombotic (plasminogen activator inhibitor 1) markers were not affected. Glucose and lipids were also analyzed after 1 and 5 wk of intervention and were not affected by the intervention.
CONCLUSION: When incorporated into a habitual diet, consumption of test foods with a decreased GL does not ameliorate metabolic risk markers in overweight subjects.
Ruth Vrolix; Ronald P Mensink
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-05-26
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-12     Revised Date:  2011-01-05    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-74     Citation Subset:  AIM; IM    
Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands.
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MeSH Terms
Biological Markers / blood
Blood Glucose / metabolism*
Cholesterol / blood
Cross-Over Studies
Dietary Carbohydrates / metabolism*
Double-Blind Method
Glycemic Index*
Inflammation Mediators / blood
Insulin / blood*
Lipids / blood*
Metabolic Syndrome X / etiology*
Middle Aged
Overweight / blood*
Plasminogen Activator Inhibitor 1 / blood
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Inflammation Mediators; 0/Lipids; 0/Plasminogen Activator Inhibitor 1; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol
Comment In:
Am J Clin Nutr. 2011 Jan;93(1):221-2; author reply 222   [PMID:  21068348 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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