| Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome. | |
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MedLine Citation:
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PMID: 20504977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epidemiologic studies suggest that diets with a low glycemic index (GI) or glycemic load (GL) are associated with a decreased risk of developing metabolic syndrome. Intervention studies are inconsistent, however, possibly due to differences in macronutrient and fiber compositions of the experimental diets. OBJECTIVE: We tested side-by-side test foods with similar macronutrient and fiber compositions but with different sucrose-flour ratios or carbohydrate source to determine the effects of different GIs and GLs on metabolic risk markers in overweight subjects. DESIGN: Overweight men (n = 9) and women (n = 6) received in random order for 11 wk 4 test foods with an increased GI or a decreased GI (69 compared with 40, 86 compared with 48, 63 compared with 37, and 51 compared with 20, respectively). There was a GL difference of 32 units between the 2 interventions. RESULTS: At the end of the 11-wk intervention periods, the decreased GL test foods did not change fasting plasma glucose (mean +/- SD: 5.83 +/- 0.6 compared with 5.94 +/- 0.6 mmol/L) or insulin (8.3 +/- 2.8 compared with 9.8 +/- 5.1 mU/L) concentrations compared with increased GL test foods. Serum total cholesterol (5.56 +/- 0.90 compared with 5.76 +/- 1.04 mmol/L), LDL-cholesterol (3.57 +/- 0.72 compared with 3.68 +/- 0.80 mmol/L), HDL-cholesterol (1.21 +/- 0.38 compared with 1.24 +/- 0.37 mmol/L), and triacylglycerol (1.61 +/- 0.77 compared with 1.78 +/- 1.04 mmol/L) concentrations were also not significantly different for decreased and increased GL test foods, respectively. Finally, proinflammatory (high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, monocyte chemoattractant protein 1) and prothrombotic (plasminogen activator inhibitor 1) markers were not affected. Glucose and lipids were also analyzed after 1 and 5 wk of intervention and were not affected by the intervention. CONCLUSION: When incorporated into a habitual diet, consumption of test foods with a decreased GL does not ameliorate metabolic risk markers in overweight subjects. |
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Authors:
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Ruth Vrolix; Ronald P Mensink |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-12 Revised Date: 2011-01-05 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 366-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands. r.vrolix@hb.unimaas.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Blood Glucose / metabolism* Cholesterol / blood Cross-Over Studies Dietary Carbohydrates / metabolism* Double-Blind Method Female Glycemic Index* Humans Inflammation Mediators / blood Insulin / blood* Lipids / blood* Male Metabolic Syndrome X / etiology* Middle Aged Overweight / blood* Plasminogen Activator Inhibitor 1 / blood Risk Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Inflammation Mediators; 0/Lipids; 0/Plasminogen Activator Inhibitor 1; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2011 Jan;93(1):221-2; author reply 222
[PMID:
21068348
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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