Document Detail

Effects of gluconeogenic precursor flux alterations on glycogen resynthesis after prolonged exercise.
MedLine Citation:
PMID:  3693208     Owner:  NLM     Status:  MEDLINE    
The importance of gluconeogenic substrates (i.e., lactate, glycerol, and alanine) in the glycogen resynthesis observed in fasting rats after exhausting submaximal exercise [R.D. Fell et al. Am. J. Physiol. 238 (Regulatory Integrative Comp. Physiol. 7): R328-R332, 1980] was examined in muscles and liver in response to pharmacological alterations of gluconeogenic precursor flux. The minor role of lactate for glycogen resynthesis after prolonged submaximal exercise was confirmed by the insignificant accumulation of lactate neither in muscles nor in plasma. When the rate of lipolysis is reduced either by beta-blockade or by nicotinic acid injection, the replenishment of muscle glycogen persisted, suggesting that glycerol released by triglycerides hydrolysis did not play an important role in glycogen resynthesis. On the other hand, when pyruvate oxidation is enhanced by dichloroacetate (DCA), thus reducing plasma levels of lactate and alanine, glycogen resynthesis was completely blocked in liver and partly in some but not all muscles. This failure in total inhibition of glycogen resynthesis associated with the significant reduction of the plasma alanine level could be attributed to the possible stimulation of gluconeogenesis from alanine by DCA (R.A. Harris and D.W. Crabb. Arch. Biochem. Biophys. 189: 364-371, 1978). The results could point out alanine as the major gluconeogenic substrate during recovery from exhaustive exercise in fasting conditions.
R J Favier; H E Koubi; M H Mayet; B Semporé; B Simi; R Flandrois
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  63     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-01-27     Completed Date:  1988-01-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1733-8     Citation Subset:  IM; S    
Unité Associeé 0621, Centre National de la Recherche Scientifique, Laboratoire de Physiologie A, Lyon, France.
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MeSH Terms
Alanine / blood
Blood Glucose / metabolism
Dichloroacetic Acid / pharmacology
Fatty Acids, Nonesterified / blood
Gluconeogenesis* / drug effects
Glycerol / blood
Glycogen / biosynthesis*
Lactates / blood
Liver Glycogen / biosynthesis
Muscles / metabolism
Nicotinic Acids / pharmacology
Physical Exertion*
Propranolol / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Liver Glycogen; 0/Nicotinic Acids; 525-66-6/Propranolol; 56-41-7/Alanine; 56-81-5/Glycerol; 79-43-6/Dichloroacetic Acid; 9005-79-2/Glycogen

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