Document Detail


Effects of glucagon-like peptide-1-(7-36)-amide on pancreatic islet and intestinal blood perfusion in Wistar rats and diabetic GK rats.
MedLine Citation:
PMID:  17087662     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to evaluate the effects of GLP-1 [glucagon-like peptide-1-(7-36)-amide] on total pancreatic, islet and intestinal blood perfusion in spontaneously hyperglycaemic GK rats and normal Wistar rats using a microsphere technique. GK rats had hyperglycaemia and increased pancreatic and islet blood flow. Blood glucose concentrations were not affected when measured shortly (8 min) after GLP-1 administration in either GK or Wistar rats. GLP-1 had no effects on baseline pancreatic or islet blood flow in Wistar rats, but did prevent the blood flow increase normally seen following glucose administration to these animals. In GK rats, administration of GLP-1 decreased both pancreatic and islet blood flow. Glucose administration to the GK rats decreased pancreatic and islet blood flow. This decrease was not affected by pre-treatment with GLP-1. We conclude that administration of GLP-1 leads to a decrease in the augmented blood flow seen in islets of diabetic GK rats. The GLP-1-induced action on islet blood perfusion may modulate output of islet hormones and contribute to the antidiabetogenic effects of the drug in Type 2 diabetes (non-insulin-dependent diabetes).
Authors:
Annika M Svensson; Claes-Göran Ostenson; Suad Efendic; Leif Jansson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  112     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
Affiliation:
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / drug effects,  metabolism
Colon / blood supply
Diabetes Mellitus, Experimental / blood,  physiopathology*
Duodenum / blood supply
Female
Glucagon-Like Peptide 1 / pharmacology*
Insulin / blood
Intestines / blood supply*
Islets of Langerhans / blood supply*
Microspheres
Pancreas / blood supply
Peptide Fragments / pharmacology*
Rats
Rats, Wistar
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Peptide Fragments; 11061-68-0/Insulin; 119637-73-9/glucagon-like peptide 1 (7-36)amide; 89750-14-1/Glucagon-Like Peptide 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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