| Effects of glibenclamide and nicorandil in post-ischaemic contractile dysfunction of perfused hearts in normotensive and spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 8818933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We have demonstrated previously that nicorandil, an ATP-sensitive potassium channel opener, improved post-ischaemic contractile dysfunction of perfused hearts in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats dose-dependently. This study aimed to characterize the effect of glibenclamide, an ATP-sensitive potassium channel blocker, and nicorandil in post-ischaemic contractile dysfunction of SHR and WKY rats. METHODS: The perfused hearts were subjected to 30 min of global ischaemia and then 30 min of reperfusion. Administration of 10 or 50 mumol/l glibenclamide or of a combination of glibenclamide and 300 mumol/l nicorandil was performed for 10 min before the ischaemia. The left ventricular developed pressure and end-diastolic pressure were measured. RESULTS: Postischaemic contractile function was better in WKY rats than it was in SHR. Neither glibenclamide nor a combination of glibenclamide and nicorandil influenced the postischaemic contractile function or increased the incidence of reperfusion arrhythmias. The recoveries of coronary flow and heart rate after reperfusion were poor and the incidence of reperfusion arrhythmias was low in SHR. CONCLUSIONS: These results suggest that nicorandil improves postischaemic contractile dysfunction via a mechanism involving ATP-sensitive potassium channel opening both in SHR and in WKY rats. The hypertensive hearts were more susceptible to cardiac reperfusion dysfunction, compared with normal hearts. |
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Authors:
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C Nakagawa; J Asayama; T Tatsumi; S Matoba; M Kobara; T Tanaka; B Ohta; A Kawahara; K Tsuruyama; M Katamura; M Nakagawa |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 14 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1997-01-16 Completed Date: 1997-01-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 921-6 Citation Subset: IM |
Affiliation:
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Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Volume Creatine Kinase / drug effects, metabolism Glyburide / pharmacology* Heart Rate / drug effects Hemodynamics / drug effects Hypertension / complications* Male Myocardial Contraction / drug effects* Myocardial Reperfusion Injury / prevention & control* Niacinamide / analogs & derivatives*, pharmacology Nicorandil Rats Rats, Inbred SHR Rats, Inbred WKY Time Factors |
| Chemical | |
Reg. No./Substance:
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10238-21-8/Glyburide; 65141-46-0/Nicorandil; 98-92-0/Niacinamide; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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