Document Detail

Effects of ginsenosides on impaired performance caused by scopolamine in rats.
MedLine Citation:
PMID:  8894589     Owner:  NLM     Status:  MEDLINE    
The effects of five structurally different ginsenosides on the performance impaired by scopolamine in rats were studied in a radial-arm maze. Ginsenoside Re had an ameliorating effect, but the ginsenosides, 20-O-glucosyl-protopanaxadiol, F2, Rf, and Rh1, did not. We reported previously that ginsenoside Rg1 had an ameliorating effect but that ginsenosides Rb1 and Rd did not (Yamaguchi et al., 1995, Psychoneuroendocrinology 20, 645). The sugar moieties at C(6) and C(20), which are possessed by Re and Rg1, seem to be indispensable for an ameliorating effect on the performance impaired by scopolamine.
Y Yamaguchi; M Higashi; H Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  312     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-03-31     Completed Date:  1997-03-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  149-51     Citation Subset:  IM    
Research Laboratory, Zenyaku Kogyo, Co., Ltd., Tokyo, Japan.
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MeSH Terms
Behavior, Animal / drug effects*
Dose-Response Relationship, Drug
Learning / drug effects
Rats, Sprague-Dawley
Saponins / pharmacology*
Reg. No./Substance:
0/Ginsenosides; 0/Saponins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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