Document Detail


Effects of ginger on gastric emptying and motility in healthy humans.
MedLine Citation:
PMID:  18403946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Ginger has been reported to improve upper gastrointestinal symptoms. Little information about the effects of ginger on gastric motor function, exists, however. Our aim was to investigate the effects of ginger on gastric emptying, antral motility, proximal gastric dimensions, and postprandial symptoms. METHODS: Twenty-four healthy volunteers were studied twice in a randomized double-blind manner. After an 8 h fast, the volunteers ingested three ginger capsules (total 1200 mg) or placebo, followed after 1 h by 500 ml low-nutrient soup. Antral area, fundus area and diameter, and the frequency of antral contractions were measured using ultrasound at frequent intervals over 90 min, and the gastric half-emptying time was calculated from the change in antral area. Gastrointestinal sensations and appetite were scored using visual analog questionnaires. Data are expressed in terms of mean+/-standard error. RESULTS: Antral area decreased more rapidly (P<0.001) and the gastric half-emptying time was less after ginger than placebo ingestion (13.1+/-1.1 vs. 26.7+/-3.1 min, P<0.01), whereas the frequency of antral contractions was greater (P<0.005). Fundus dimensions did not differ, and there was no significant difference in any gastrointestinal symptoms. CONCLUSION: Ginger accelerates gastric emptying and stimulates antral contractions in healthy volunteers. These effects could potentially be beneficial in symptomatic patient groups.
Authors:
Keng-Liang Wu; Christopher K Rayner; Seng-Kee Chuah; Chi-Sin Changchien; Sheng-Nan Lu; Yi-Chun Chiu; King-Wah Chiu; Chuan-Mo Lee
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  20     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-11     Completed Date:  2008-08-21     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-40     Citation Subset:  IM    
Affiliation:
Division of Hepatogastroenterology, Department of Internal Medicine, College of Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan. kengliang_wu@yahoo.com.tw
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MeSH Terms
Descriptor/Qualifier:
Adult
Double-Blind Method
Gastric Emptying / drug effects
Gastrointestinal Motility / drug effects*
Ginger*
Humans
Male
Muscle Contraction / drug effects
Phytotherapy*
Plant Extracts / pharmacology
Postprandial Period
Pyloric Antrum / physiology
Sensation / drug effects
Chemical
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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