Document Detail

Effects of gestational and lactational exposure to TCDD or coplanar PCBs on spatial learning.
MedLine Citation:
PMID:  8725643     Owner:  NLM     Status:  MEDLINE    
Recently we reported that in utero and lactational exposure to specific ortho-substituted polychlorinated biphenyl (PCB) congeners resulted in a learning deficit on a delayed spatial alternation (DSA) task in female rats. In this study, spatial learning and memory was assessed following in utero and lactational exposure to coplanar PCBs or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Time-mated Sprague-Dawley rats were dosed with PCB 77 (3,3',4,4'-tetrachlorobiphenyl), 2 or 8 mg/kg/day; PCB 126 (3,3',4,4',5-pentachlorobiphenyl), 0.25 or 1.0 micrograms/kg/day; TCDD, 0.025 or 0.1 micrograms/kg/day; or corn oil vehicle via gavage on gestation days 10-16. Litters were culled to eight on day 2 and weaned on day 21. Beginning on day 80, one male and one female from each litter were tested on an eight-arm radial maze working memory task. The TCDD-exposed rats displayed pronounced decreases in errors relative to controls. PCB 77- and PCB 126-exposed rats showed similar, but less pronounced, decreases in errors. The same animals were later tested on a T-maze DSA task, but no differences among groups were observed. In conclusion, perinatal exposure to low doses of TCDD or structurally related coplanar PCBs appeared to facilitate acquisition of a working memory task on the radial arm maze. This effect was very different from that previously observed in rats exposed to ortho-substituted PCB congeners. The rats exposed to ortho-substituted PCBs did not differ from controls on the radial arm maze and were impaired on the T-maze DSA task. Together these findings suggest that coplanar and ortho-substituted PCBs may have different mechanisms of action on the CNS.
S L Schantz; B W Seo; J Moshtaghian; R E Peterson; R W Moore
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  18     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-13     Citation Subset:  IM    
Institute for Environmental Studies and Neuroscience Program, University of Illinois at Urbana-Champaign, 61801, USA.
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MeSH Terms
Maze Learning / drug effects*
Polychlorinated Biphenyls / toxicity*
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Tetrachlorodibenzodioxin / toxicity*
Grant Support
Reg. No./Substance:
0/Polychlorinated Biphenyls; 1746-01-6/Tetrachlorodibenzodioxin; 32598-13-3/3,4,3',4'-tetrachlorobiphenyl; 32774-16-6/3,4,5,3',4',5'-hexachlorobiphenyl

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