Document Detail


Effects of gestational alcohol exposure on the fatty acid composition of umbilical cord serum in humans.
MedLine Citation:
PMID:  10617986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of maternal periconceptional alcohol intake on polyunsaturated fatty acid (PUFA) concentrations in human neonates. The area percentage of each fatty acid in cord blood serum from 12 infants born to control women (who consumed <2 mL absolute ethanol/d) was compared with that of 9 infants born to women whose periconceptional alcohol intake averaged > or = 30mL absolute ethanol/d. Periconceptional alcohol use was associated with a 30% increase in the proportion of docosahexaenoic acid (22:6n-3) in cord blood (3.0% of total lipid in control infants compared with 3.9% in alcohol-exposed infants; P < 0.01). The rise in the proportion of 22:6n-3 was responsible for increases in the ratio of n-3 to n-6 fatty acids and the ratio of long-chain n-3 to n-6 fatty acids (P < 0.055). Examination of the lipid-class fatty acid profile indicated that serum lipid alterations were localized to the cholesterol esters; 22:6n-3 in the cholesterol esters of alcohol-exposed infants increased 54% (P < 0.011) and arachidonic acid increased 55% (P < 0. 005). The relative fatty acyl composition of maternal serum showed a significant increase in 18:0 fatty acids in the alcohol-exposed group (25%, P < 0.005) but there were no changes in the other fatty acids. The increase in the proportion of 22:6n-3 was unexpected but is consistent with the hypothesis that this essential lipid may be conserved selectively. These results imply that the lifelong neurobehavioral and sensory dysfunction in fetal alcohol syndrome and other alcohol-related neurodevelopmental disorders may be due in part to PUFA dysregulation.
Authors:
Y M Denkins; J Woods; J E Whitty; J H Hannigan; S S Martier; R J Sokol; N Salem
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  71     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-04     Completed Date:  2000-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300S-6S     Citation Subset:  AIM; IM    
Affiliation:
National Institute on Alcoholism and Alcohol Abuse (NIAAA), Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, Rockville, MD 20852, USA. denkinym@mhs.pbrc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alcohol Drinking / adverse effects*,  blood
Alcoholic Beverages / adverse effects
Cholesterol Esters / blood
Educational Status
Fatty Acids, Unsaturated / blood*
Female
Fetal Blood / chemistry*
Humans
Infant, Newborn
Phospholipids / blood
Pregnancy
Pregnancy Complications / blood*
Smoking
Social Class
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
P50-AA07606/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Triglycerides
Comments/Corrections
Erratum In:
Am J Clin Nutr 2000 Apr;71(4):1011

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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