Document Detail

Effects of germfree status and food restriction on longevity and growth of mice.
MedLine Citation:
PMID:  1748169     Owner:  NLM     Status:  MEDLINE    
An investigation was undertaken to study the effects of germfree (GF) status and mild food restriction on life span in GF and specific pathogen-free (SPF) male ICR mice either full-fed (ad libitum) or on a restricted diet of 4.5 grams per day (equivalent to approximately 80% of full-fed intake) from five-week-old. The mean life span of the full-fed SPF and GF mice was 75.9 and 88.9 weeks respectively, while the mean life span of the food-restricted SPF and GF mice was 117.5 and 109.6 weeks, respectively. Mice in both GF and SPF food-restricted groups were characterized by lower body weight and increased survival. These findings suggest that the cessation of growth may be importantly and perhaps causally related to longevity. The GF mice survived longer than the SPF mice, but the combination of GF status with food restriction did not seem to extend life span more than food restriction alone.
S Tazume; K Umehara; H Matsuzawa; H Aikawa; K Hashimoto; S Sasaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Jikken dobutsu. Experimental animals     Volume:  40     ISSN:  0007-5124     ISO Abbreviation:  Jikken Dobutsu     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256412     Medline TA:  Jikken Dobutsu     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
Department of Microbiology, School of Medicine, Tokai University, Kanagawa, Japan.
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MeSH Terms
Body Weight
Diet, Reducing*
Germ-Free Life*
Organ Size

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