Document Detail

Effects of genetic selection on growth rate and intestinal structure in the domestic fowl (Gallus domesticus).
MedLine Citation:
PMID:  1979266     Owner:  NLM     Status:  MEDLINE    
1. Pieces of small intestine taken from chickens subjected previously to continuous selection, relaxed selection or no selection for rapid growth were used to estimate villus surface area and microvillus development to determine what effects genetic selection might have on factors controlling intestinal function. 2. Crypt size and the rates at which enterocytes migrated out of crypts were also measured, after injection of tritiated thymidine, to determine the time course of microvillus elongation. 3. Differences in growth rates measured between highly selected, relaxed selected or unselected birds were found to be correlated with parallel changes in villus surface area. Selection for growth did not change the density, dimensions or pattern of development of enterocyte microvilli. Microvilli did, however, produce a maximal 20-fold increase in villus surface area under all conditions. 4. Crypt size and enterocyte migration rates did not vary significantly between tissue taken from unselected and relaxed selected chickens. Tissue taken from highly selected birds had a crypt size and enterocyte migration rate 40% higher than values found for the other two groups of chickens. 5. The possibility that early genetic selection increased growth potential by uncoupling diet-induced changes on crypt hyperplasia from secondary effects on villus structure, and that later selection increased growth potential by increasing appetite, is discussed.
M W Smith; M A Mitchell; M A Peacock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. A, Comparative physiology     Volume:  97     ISSN:  0300-9629     ISO Abbreviation:  Comp Biochem Physiol A Comp Physiol     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-22     Completed Date:  1991-01-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1276312     Medline TA:  Comp Biochem Physiol A Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-63     Citation Subset:  IM    
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
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MeSH Terms
Cell Movement
Chickens / anatomy & histology,  genetics*,  growth & development
Intestine, Small / anatomy & histology*,  growth & development,  physiology
Microvilli / ultrastructure
Selection, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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