Document Detail

Effects of general anesthesia on plasma colloid oncotic pressure in dogs.
MedLine Citation:
PMID:  20113243     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the magnitude of the change in colloid oncotic pressure (COP) associated with general anesthesia in dogs undergoing a variety of elective procedures. DESIGN: Cohort study. ANIMALS: 50 client-owned dogs. PROCEDURES: For each dog, preanesthetic and postanesthetic PCV, plasma total solids (TS) concentration, and COP were determined. The procedures requiring anesthesia, volume of crystalloid fluids administered IV, duration of anesthesia, age, weight, and sex were recorded. RESULTS: Postanesthetic PCV (mean +/- SD, 41.8 +/- 5.4%), TS concentration (6.3 +/- 0.8 g/dL), and COP (19.4 +/- 3.6 mm Hg) were significantly decreased, compared with preanesthetic values (48.8 +/- 5.9%, 7.2 +/- 0.7 g/dL, and 24.4 +/- 4.2 mm Hg, respectively). None of the variables tested could be used to reliably predict changes in COP. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that COP in healthy dogs may decrease by 5 mm Hg on average after general anesthesia and that this decrease may not be reliably predicted by the volume of fluids administered IV during anesthesia or by the concurrent measured decrease in TS concentration.
David I Dismukes; Elizabeth J Thomovsky; F A Mann; John R Middleton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  236     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-11     Citation Subset:  IM    
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
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MeSH Terms
Anesthesia, General / veterinary*
Anesthetics, Inhalation / pharmacology
Anesthetics, Intravenous / pharmacology
Blood Proteins / physiology*
Colloids / metabolism*
Isotonic Solutions / administration & dosage,  pharmacology
Osmotic Pressure / physiology*
Rehydration Solutions / administration & dosage,  pharmacology
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Blood Proteins; 0/Colloids; 0/Isotonic Solutions; 0/Rehydration Solutions; 0/crystalloid solutions

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