| Effects of gender, body composition, and menopause on plasma concentrations of leptin. | |
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MedLine Citation:
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PMID: 8784109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circulating concentrations of leptin ([leptin]) vary directly with body mass index and percentage body fat, and may thus constitute an afferent limb of a system regulating body fatness. We tested the hypotheses that: 1) Plasma [leptin] vary more directly with absolute fat mass than with fractional body fatness per se: and 2). The relationship between fat mass and [leptin] is significantly affected by gender and by menopausal status. [Leptin] in the post-absorptive state was examined in 67 subjects (26 male, 20 premenopausal female, 21 postmenopausal females; 43 never-obese, 24 obese) at usual body weight. Body composition was determined by hydrodensitometry, and [leptin] was determined by a double antibody ELISA assay. In male and pre-menopausal female subjects, subcutaneous adipose tissue aspirations were performed for determination of adipocyte volume by the osmium fixation method, and a 3 hour oral glucose tolerance tests was performed. At usual body weight, ([leptin]) was better correlated with absolute fat mass than with body mass index (BMI) or percentage body fat. BMI and % body fat did not account for any of the variance in [leptin] beyond that attributable to FM, per se. The regression equations relating FM to [leptin] did not differ significantly between obese and never-obese subjects. [Leptin] and fasting serum insulin concentrations were significantly correlated in males only. [Leptin] was significantly higher in pre- and post-menopausal females compared to males, even when [leptin] was corrected for differences in body composition (pre-menopausal females > post-menopausal females > males). While plasma [leptin], corrected for FM, declines significantly in women post-menopause, this decline is not sufficient to account for the striking sexual dimorphism in the relationship of leptin to fat mass. This sexual dimorphism is apparently also due, in part, to a suppressive effect of circulating androgens on [leptin]. |
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Authors:
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M Rosenbaum; M Nicolson; J Hirsch; S B Heymsfield; D Gallagher; F Chu; R L Leibel |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 81 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-10-16 Completed Date: 1996-10-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3424-7 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, NY 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue Adult Aged Aged, 80 and over Body Composition* Body Mass Index Female Humans Leptin Male Menopause / blood* Middle Aged Postmenopause / blood Premenopause / blood Proteins / metabolism* Sex Characteristics* |
| Grant Support | |
ID/Acronym/Agency:
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DK01983/DK/NIDDK NIH HHS; DK26687/DK/NIDDK NIH HHS; DK30583/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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