Document Detail

Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity.
MedLine Citation:
PMID:  9805647     Owner:  NLM     Status:  MEDLINE    
Obesity is a prevalent metabolic disorder associated with high morbidity and mortality rates. Medical treatment rarely succeeds, and bariatric surgery has been proposed as an alternative therapy. The purpose of this non-controlled retrospective study was to evaluate time-course changes in body weight in severely obese patients who underwent vertical ring gastroplasty or adjustable silicone gastric banding, and to assess the prevalence and potential reversibility of several of the biological abnormalities associated with morbid obesity. From an initial cohort comprising 658 patients, regular body weight measurements and biological data were obtained in 505 patients [419 females, 86 males; age 36 +/- 11 years; body mass index 42.7 +/- 6.9 kg/m2; (mean +/- SD)] with a mean follow-up of 26 +/- 14 months. Mean weight loss was 32 +/- 16 kg. Most weight reduction occurred within the first 6 months, followed by near-stabilisation or even slight weight regain. Most biological parameters were obtained before surgery and after at least 6 months of follow-up. The high prevalence and severity of metabolic disturbances associated with the insulin resistance syndrome (hyperglycaemia, hyperinsulinaemia, decreased HDL cholesterol, hypertriglyceridaemia, elevated fibrinogen levels and hyperuricaemia) before gastroplasty were significantly decreased after weight loss. No major biological deficiencies were observed following gastroplasty, except low iron serum levels. It is concluded that marked weight loss associated with gastroplasty involved a remarkable reduction in the prevalence and severity of several biological abnormalities classically considered as cardiovascular risk factors.
F H Luyckx; A J Scheen; C Desaive; W Dewe; J E Gielen; P J Lefebvre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes & metabolism     Volume:  24     ISSN:  1262-3636     ISO Abbreviation:  Diabetes Metab.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-02     Completed Date:  1998-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  355-61     Citation Subset:  IM    
Department of Medicine, CHU Sart Tilman, Liège, Belgium.
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MeSH Terms
Belgium / epidemiology
Body Mass Index
Body Weight*
Cholesterol / blood
Cholesterol, HDL / blood
Cohort Studies
Fibrinogen / analysis
Follow-Up Studies
Hyperglycemia / epidemiology
Hyperinsulinism / epidemiology
Hypertriglyceridemia / epidemiology
Insulin / blood
Insulin Resistance
Obesity, Morbid / blood,  physiopathology*,  surgery*
Severity of Illness Index
Triglycerides / blood
Uric Acid / blood
Weight Loss
Reg. No./Substance:
0/Cholesterol, HDL; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 69-93-2/Uric Acid; 9001-32-5/Fibrinogen

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