| Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. | |
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MedLine Citation:
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PMID: 12891227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Garlic (Allium sativum L.) is a commonly used food and herbal supplement. The objective of this study was to assess in healthy volunteers (N = 14) the influence of a garlic extract on the activity of cytochrome P450 (CYP) 2D6 and 3A4. Probe substrates dextromethorphan (CYP2D6) and alprazolam (CYP3A4) were administered orally at baseline and again after treatment with garlic extract (3 x 600 mg twice daily) for 14 days. Urinary dextromethorphan/dextrorphan ratios and alprazolam plasma concentrations were determined by HPLC at baseline and after garlic extract treatment. The ratio of dextromethorphan to its metabolite was 0.044 +/- 0.48 at baseline and 0.052 +/- 0.095 after garlic supplementation. There were no significant differences between the baseline and garlic phases (P > or =.05). For alprazolam, there were no significant differences in pharmacokinetic parameters at baseline and after garlic extract treatment (all P values > or =.05; maximum concentration in plasma, 27.3 +/- 2.6 ng/mL versus 27.3 +/- 4.8 ng/mL; time to reach maximum concentration in plasma, 1.9 +/- 1.4 h versus 2.4 +/- 1.8 h; area under the time-versus-concentration curve, 537 +/- 94 h. ng. mL(-1) versus 548 +/- 159 h. ng. mL(-1); half-life of elimination, 13.7 +/- 4.4 h versus 14.5 +/- 4.3 h). Our results indicate that garlic extracts are unlikely to alter the disposition of coadministered medications primarily dependent on the CYP2D6 or CYP3A4 pathway of metabolism. |
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Authors:
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John S Markowitz; C Lindsay Devane; Kenneth D Chavin; Robin M Taylor; Ying Ruan; Jennifer L Donovan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 74 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-31 Completed Date: 2003-08-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 170-7 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC 29425, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alprazolam / pharmacokinetics Area Under Curve Biotransformation Chromatography, High Pressure Liquid Cytochrome P-450 CYP2D6 / metabolism* Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System / metabolism* Dextromethorphan / pharmacokinetics Dietary Supplements* Female Garlic* Half-Life Humans Isoenzymes / metabolism Male Sulfinic Acids / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R21 AT 00511/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/Sulfinic Acids; 125-71-3/Dextromethorphan; 28981-97-7/Alprazolam; 539-86-6/allicin; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.13.67/CYP3A4 protein, human; EC 1.14.14.1/CYP3A protein, human; EC 1.14.14.1/Cytochrome P-450 CYP2D6; EC 1.14.14.1/Cytochrome P-450 CYP3A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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