Document Detail

Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells.
MedLine Citation:
PMID:  1315459     Owner:  NLM     Status:  MEDLINE    
In this study it is shown that gamma-linolenic acid (GLA) at concentrations of 10, 20 and 50 micrograms/ml has a dose-responsive inhibitory effect on mitosis in osteogenic sarcoma cells after exposure for 24, 48 and 72 hours, respectively. GLA also has marked effects on the morphology of the nucleus and nucleolus of these cells. Decreased silver staining of nuclear phosphoproteins was also evident in GLA-supplemented cells.
M de Kock; J C Seegers; H J Els
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  81     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-02     Completed Date:  1992-06-02     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / pharmacology*
Cell Nucleolus / drug effects
Cell Nucleus / drug effects*
Linolenic Acids / pharmacology*
Mitosis / drug effects*
Mitotic Index / drug effects
Osteosarcoma / pathology*,  ultrastructure
Tumor Cells, Cultured
gamma-Linolenic Acid
Reg. No./Substance:
0/Antineoplastic Agents; 0/Linolenic Acids; 78YC2MAX4O/gamma-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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