| Effects of gallic acid on brain lipid peroxide and lipid metabolism in streptozotocin-induced diabetic Wistar rats. | |
| | |
MedLine Citation:
|
PMID: 20957663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study evaluated the protective effects of gallic acid on brain lipid peroxidation products, antioxidant system, and lipids in streptozotocin-induced type II diabetes mellitus. Streptozotocin-induced diabetic rats showed a significant increase in the levels of blood glucose, brain lipid peroxidation products, and lipids and a significant decrease in the activities of brain enzymic antioxidants. Oral treatment with gallic acid (10 mg and 20 mg/kg) for 21 days significantly decreased the levels of blood glucose, brain lipid peroxidation products, and lipids and significantly increased the activities of brain enzymic antioxidants in diabetic rats. Histopathology of brain confirmed the protective effects of gallic acid. Furthermore, in vitro study revealed the free radical scavenging action of gallic acid. Thus, our study shows the beneficial effects of gallic acid on brain metabolism in streptozotocin-induced type II diabetic rats. A diet containing gallic acid may be beneficial to type II diabetic patients. |
| | |
Authors:
|
P Stanely Mainzen Prince; M R Kumar; C J Selvakumari |
Related Documents
:
|
22368783 - Encapsulated islets transplantation: past, present and future. 9371913 - Diabetics do not have increased alzheimer-type pathology compared with age-matched cont... 182473 - Effect of glucose on adenosine 3', 5'-monophosphate levels in rat pancreatic islets. |
Publication Detail:
|
Type: Journal Article Date: 2010-10-18 |
Journal Detail:
|
Title: Journal of biochemical and molecular toxicology Volume: 25 ISSN: 1099-0461 ISO Abbreviation: J. Biochem. Mol. Toxicol. Publication Date: 2011 Mar-Apr |
Date Detail:
|
Created Date: 2011-04-07 Completed Date: 2011-07-25 Revised Date: 2011-09-16 |
Medline Journal Info:
|
Nlm Unique ID: 9717231 Medline TA: J Biochem Mol Toxicol Country: United States |
Other Details:
|
Languages: eng Pagination: 101-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar 608 002, India. ps_mainzenprince@yahoo.co.in |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Antioxidants / pharmacology* Biphenyl Compounds / metabolism Blood Glucose / analysis Brain / pathology Diabetes Mellitus, Experimental / drug therapy*, physiopathology Gallic Acid / pharmacology* Lipid Metabolism / drug effects* Lipid Peroxidation Lipid Peroxides / metabolism* Lipids / blood Male Picrates / metabolism Rats Rats, Wistar Streptozocin / toxicity Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Biphenyl Compounds; 0/Blood Glucose; 0/Lipid Peroxides; 0/Lipids; 0/Picrates; 0/Thiobarbituric Acid Reactive Substances; 149-91-7/Gallic Acid; 18883-66-4/Streptozocin; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in te...
Next Document: Intent-to-treat: further insight.