Document Detail


Effects of frusemide on electrolyte and acid-base balance during exercise.
MedLine Citation:
PMID:  10659284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken to evaluate the effects of frusemide on the concentration of plasma electrolytes and the relationship between changes in electrolyte concentration and the simultaneous changes in acid-base balance in arterial and venous blood during intense exercise. Five exercise-conditioned Thoroughbred horses were exercised on a high-speed treadmill at a slope of 10% at speeds known to exceed VO2max. Horses participated in 3 randomised exercise trials in which they received either placebo (control), low-dose frusemide (0.5 mg/kg bwt), or high-dose frusemide (1.0 mg/kg) 4 h prior to exercise. Arterial and mixed venous blood samples were drawn before, during and after intense exercise. Packed cell volume (PCV), plasma protein, plasma electrolyte, plasma lactate concentrations and acid-base balance were determined. Frusemide at both dosages induced a significant metabolic alkalosis associated with a decrease in plasma çhloride[ in both arterial and mixed venous blood. There was a highly significant correlation between the strong ion difference (SID) and bicarbonate[ in all blood samples. The effects of frusemide on electrolyte concentration and acid-base balance were largely due to changes in SID.
Authors:
G P Carlson; J H Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2000-03-02     Completed Date:  2000-03-02     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  370-4     Citation Subset:  IM    
Affiliation:
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium / drug effects*
Animals
Diuretics / pharmacology*
Exercise Test / veterinary
Furosemide / pharmacology*
Horses / physiology*
Models, Biological
Physical Conditioning, Animal / physiology*
Water-Electrolyte Balance / drug effects*
Chemical
Reg. No./Substance:
0/Diuretics; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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